Lab-on-a-Graphene: Functionalized Graphene Transistors and Their Application for Biosensing
Lab-on-a-Graphene: Functionalized Graphene Transistors and Their Application for Biosensing
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石墨烯实验室：功能化石墨烯晶体管及其在生物传感中的应用
DOI：
10.1007/978-3-319-61651-3_4
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Matsumoto Kazuhiko
中科院分区：
文献类型：
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作者：
Ono Takao;Kanai Yasushi;Ohno Yasuhide;Maehashi Kenzo;Inoue Koichi;Matsumoto Kazuhiko
石墨烯是一种二维材料，其表现出任何已知材料中最高的载流子迁移率。石墨烯的独特特性允许石墨烯场效应晶体管（G-FET）在带电分子接触石墨烯沟道时灵敏地响应。这种响应特性为生物传感提供了希望，这需要对目标生物分子进行高度灵敏的检测。本文综述了我们在G-FET生物传感方面的最新成果。首先，描述G-FET生物传感背后的基本原理。接下来，我们报告了使用G-FET的生物传感的几个例子，其中DNA分子，抗体和其他受体分别固定在石墨烯通道上，以允许选择性检测相应的目标分子。最后，我们描述了G-FET的进一步功能化，用于无线操作，并提供灵活的传感器。受体和器件结构对G-FET的功能化导致了作者命名为“石墨烯实验室”的生物传感平台。
Graphene is a two-dimensional material that exhibits the highest carrier mobility of any known material. The unique characteristics of graphene allow graphene field-effect transistors (G-FETs) to respond sensitively when charged molecules contact the graphene channel. This response characteristic holds promise for biosensing, which requires the highly sensitive detection of target biomolecules. This article reviews our recent achievements in G-FET biosensing. First, the basic principle behind G-FET biosensing is described. Next, we report several examples of biosensing using G-FETs in which DNA molecules, antibodies, and other receptors were separately immobilized onto graphene channels to allow selective detection of the respective target molecule. Finally, we describe the further functionalization of G-FETs for wireless operation and to provide flexible sensors. Functionalization of G-FETs by receptors and device structures led to a biosensing platform that the authors have named “lab-on-a-graphene.”