Innate Immunity Acts as the Major Regulator in Talaromyces marneffei Coinfected AIDS Patients: Cytokine Profile Surveillance During Initial 6-Month Antifungal Therapy
Innate Immunity Acts as the Major Regulator in Talaromyces marneffei Coinfected AIDS Patients: Cytokine Profile Surveillance During Initial 6-Month Antifungal Therapy
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先天免疫是马尔尼菲踝节菌合并感染艾滋病患者的主要调节者：最初 6 个月抗真菌治疗期间的细胞因子谱监测。
DOI：
10.1093/ofid/ofz205
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发表时间：
2019-06-01
影响因子：
4.2
通讯作者：
Li, Yu-Ye
中科院分区：
文献类型：
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作者：
Dong, Rong-Jing;Zhang, Yun-Gui;Li, Yu-Ye
背景由马尔尼菲Talaromycesmarneffei感染引起的Talaromycosis是一种致命的系统性真菌病，发生于免疫抑制的个体，如艾滋病患者。细胞因子和免疫细胞在抗真菌感染中起着重要作用。然而，宿主免疫系统如何响应感染和治疗迄今尚未报道。对41例合并马尔尼菲篮状菌感染的艾滋病患者进行随访，观察其在不同抗真菌治疗阶段的免疫细胞和细胞因子水平，并收集临床特征和实验室检查资料。采用相关分析方法，对影响艾滋病患者抗马尔尼菲篮状菌感染的相关因素进行分析。这41例患者的常见疾病和状况是淋巴结肿大、肝肿大和脾肿大。CD 4 + T细胞均极低。此外，促炎细胞因子（IL-12、IL-17 A、TNF-α、IFN. IL-18和IL-1 β）、抗炎细胞因子（IL-10）和趋化因子（IP-10）在治疗前的踝真菌病中观察到（P
Background. Talaromycosis caused by Talaromyces marneffei infection is a fatal systemic mycosis in immunosuppressed individuals, such as patients with AIDS. Cytokines and immunocytes play a central role against fungus infection. However, how the host immune system responds to infection and treatment has not been reported to date.Methods. Forty-one Talaromyces marneffei coinfected AIDS patients were followed up, their immunocytes and cytokine profiles were obtained at different antifungal treatment stages, and data on clinical features and laboratory examinations were collected. Correlation analysis was used to identify factors associated with host immunity against Talaromyces marneffei infection in AIDS patients.Results. Common diseases and conditions of these 41 patients were lymphadenopathy, hepatomegaly, and splenomegaly. CD4+ T cells were extremely low in all of them. Moreover, significant increases of proinflammatory cytokines (IL-12, IL-17A, TNF-alpha, IFN., IL-18, and IL-1 beta), anti-inflammatory cytokines (IL-10), and chemokines (IP-10) were observed in talaromycosis before treatment (P