Vasculogenesis and angiogenesis.
Vasculogenesis and angiogenesis.
复制标题
DOI：
10.1007/978-1-4419-8871-3_1
复制
发表时间：
2004
影响因子：
--
通讯作者：
Sybill Patan
中科院分区：
文献类型：
--
作者：
Sybill Patan
血管生成和血管生成这两种不同的机制实现了胚胎中血管网络的形成。血管发生产生心脏和胚胎内部及其周围膜中的第一个原始血管丛，如卵黄囊循环。血管生成负责该网络的重塑和扩张。虽然血管发生是指中胚层来源的成血管细胞的血管原位分化和生长，但血管发生包括两种不同的机制：内皮出芽和套叠微血管生长（IMG）。发芽过程基于内皮细胞迁移、增殖和管形成。 IMG 通过在血管腔中形成组织折叠和间质组织柱并将其插入来划分现有的血管腔。后者被称为间质或血管间组织结构（ITS）和组织柱或柱。 Intussusception also includes the establishment of new vessels by in situ loop formation in the wall of large veins.这些不同机制的分子调节涉及最重要的正调节因子、VEGF 及其受体 flk-1 (KDR) 和 flt-1、血管生成素/连接系统和肝配蛋白-B/EpH-B 系统。总结了病理状态下血管生成的细胞机制和分子调控，阐述了生理与病理血管生成的差异。
Two distinct mechanisms, vasculogenesis and angiogenesis implement the formation of the vascular network in the embryo. Vasculogenesis gives rise to the heart and the first primitive vascular plexus inside the embryo and in its surrounding membranes, as the yolk sac circulation. Angiogenesis is responsible for the remodeling and expansion of this network. While vasculogenesis refers to in situ differentiation and growth of blood vessels from mesodermal derived hemangioblasts, angiogenesis comprises two different mechanisms: endothelial sprouting and intussusceptive microvascular growth (IMG). The sprouting process is based on endothelial cell migration, proliferation and tube formation. IMG divides existing vessel lumens by formation and insertion of tissue folds and columns of interstitial tissue into the vessel lumen. The latter are termed interstitial or intervascular tissue structures (ITSs) and tissue pillars or posts. Intussusception also includes the establishment of new vessels by in situ loop formation in the wall of large veins. The molecular regulation of these distinct mechanisms is discussed in respect to the most important positive regulators, VEGF and its receptors flk-1 (KDR) and flt-1, the Angiopoietin/tie system and the ephrin-B/EpH-B system. The cellular mechanisms and the molecular regulation of angiogenesis in the pathological state are summarized and the differences of physiological and pathological angiogenesis elaborated.