Speed-stability paradox in DNA-scanning by zinc-finger proteins
Speed-stability paradox in DNA-scanning by zinc-finger proteins
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DOI：
10.4161/trns.23584
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发表时间：
2013-01-01
影响因子：
3.6
通讯作者：
Levy, Yaakov
中科院分区：
文献类型：
--
作者：
Iwahara, Junji;Levy, Yaakov
通过多个锌指与DNA的广泛接触可以使锌指类转录因子高度特异地与DNA结合，但也可以减缓目标搜索过程。在这里，我们介绍了锌指蛋白如何快速扫描DNA的最新见解。并讨论了这一新知识在锌指技术中的潜在应用。
Extensive contact with DNA via multiple zinc fingers allows highly specific DNA-binding of zinc-finger-class transcription factors, but can also slow the target search process. Here we introduce recent insights into how zinc-finger proteins can rapidly scan DNA. Potential application of the new knowledge to the zinc-finger-based technology is also discussed.