Metabolite concentrations in human term placentae and their changes due to delayed collection after delivery
Metabolite concentrations in human term placentae and their changes due to delayed collection after delivery
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DOI：
10.1053/plac.2002.0908
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发表时间：
2003-02-01
期刊：
影响因子：
3.8
通讯作者：
van Patot, MCT
中科院分区：
文献类型：
--
作者：
Serkova, N;Bendrick-Peart, J;van Patot, MCT
The present study was designed to quantify the major cellular metabolites in human placentae and their changes due to the confounding effect of time and subsequent hypoxia during sample collection using magnetic resonance spectroscopy (H-1-and P-31-MRS). The absolute placental concentrations of lactate, glucose, major amino acids and cellular volume/osmo-regulators, glutathione, high-energy phosphates, fatty acids, phospholipids, triglycerols, and cholesterol are reported. There were no spatial differences in metabolism or protein expression throughout the placenta. The most significant temporal changes, due to the collection time (from 1 to 25 min after delivery), were increased concentrations of lactate (r=0.996, statistically significant P
