Staphylococcus aureus skin colonization is promoted by barrier disruption and leads to local inflammation
Staphylococcus aureus skin colonization is promoted by barrier disruption and leads to local inflammation
复制标题
屏障破坏促进金黄色葡萄球菌在皮肤定植并导致局部炎症
DOI：
10.1111/exd.12083
复制
发表时间：
2014
影响因子：
3.6
通讯作者：
Schittek B
中科院分区：
文献类型：
--
作者：
Wanke I;Skabytska Y;Kraft B;Peschel A;Biedermann T;Schittek B
已描述的细菌皮肤感染实验小鼠模型表明，病原微生物可以轻易侵入表皮和真皮，产生局部感染。我们使用了一种小鼠表皮皮肤感染模型来确定胶带剥离造成的屏障破坏水平与金黄色葡萄球菌皮肤定植的持续性、伴随的皮肤炎症和感染的诱导之间的关系。此外，我们通过分析小鼠皮肤中的促炎细胞因子和抗菌肽，研究了小鼠皮肤在生理环境中对金黄色葡萄球菌定植的反应。我们发现，以前的皮肤损伤允许皮肤炎症的发展，有利于金黄色葡萄球菌的持久性，导致皮肤定植，这表明皮肤细菌和皮肤的相互依赖性。我们的研究表明，皮肤屏障缺陷有利于金黄色葡萄球菌皮肤定植，这与严重的皮肤炎症有关。
Experimental mouse models of bacterial skin infections that have been described show that pathogenic microorganisms can readily invade the epidermis and dermis to produce localized infections. We used an epicutaneous mouse skin infection model to determine how the level of barrier disruption by tape‐stripping correlates with persistence ofStaphylococcus aureusskin colonization, concomitant induction of cutaneous inflammation and infection. Furthermore, we investigated how murine skin responds toS. aureuscolonization in a physiologic setting by analysing proinflammatory cytokines and antimicrobial peptides in mouse skin. We show that previous cutaneous damage allows skin inflammation to develop and favoursS. aureuspersistence leading to cutaneous colonization, suggesting an interdependence of cutaneous bacteria and skin. Our study suggests that skin barrier defects favourS.aureusskin colonization, which is associated with profound cutaneous inflammation.