Anticancer Camptothecin-N-Poly(lactic acid) Nanoconjugates with Facile Hydrolysable Linker.
Anticancer Camptothecin-N-Poly(lactic acid) Nanoconjugates with Facile Hydrolysable Linker.
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DOI：
10.1039/c3py01245j
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发表时间：
2014
影响因子：
4.6
通讯作者：
Cheng J
中科院分区：
文献类型：
--
作者：
Yin Q;Tong R;Yin L;Fan TM;Cheng J
我们报道了一种通过可控聚合方法将CPT与聚乳酸（PLA）的末端羧酸基团通过一个容易水解的氨基酯连接体连接的策略。所获得的CPT-N-PLA缀合物能够自组装成具有所需体外物理化学性质的50-100纳米尺寸的缀合物（NC），并且对C57 BL/6小鼠中诱导的刘易斯肺癌（LLC）显示出增强的体内治疗功效。
We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.