Does allostatic load calculation method matter? Evaluation of different methods and individual biomarkers functioning by race/ethnicity and educational level
Does allostatic load calculation method matter? Evaluation of different methods and individual biomarkers functioning by race/ethnicity and educational level
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DOI：
10.1002/ajhb.22843
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发表时间：
2016-09-01
影响因子：
2.9
通讯作者：
Sparks, P. Johnelle
中科院分区：
文献类型：
--
作者：
Howard, Jeffrey T.;Sparks, P. Johnelle
目的：本研究使用2003年至2010年收集的四波国家健康和营养检查调查（NHANES）中25岁及以上成年人的全国代表性数据，检查用于计算非稳态负荷的个体健康标志物的差异，特别注意按种族划分的等级，方法采用最大似然估计因子分析。Fisher's r到z转换检验被用来确定是否观察到的差异因素loadings是统计significant.ResultsThe研究结果揭示了unidimensional的概念的非稳态负荷和潜在的差异之间的关联个体生物标志物和非稳态负荷的汇总措施。此外，代谢过程往往是所有成年人非稳态负荷的最重要预测因素;但是，在此情况下，与非西班牙裔黑人相比，炎症指标在确定非西班牙裔黑人的非稳态负荷评分方面更重要。西班牙裔白人和未受过大学教育的成年人与受过大学或大学学位的成年人相比。在人口层面上的非稳态负荷，需要更好地了解面临经济、社会和政治权力排斥的人口群体如何将这一地位内在化，这可能通过健康损害和过早衰老的不同表现，导致早期健康恶化和最终死亡机会。Am. J.哈姆。28：627-635，2016. (c)2016 Wiley Periodicals，Inc.
ObjectivesUsing nationally representative data for adults of age 25 years and older from four waves of the National Health and Nutrition Examination Survey (NHANES), collected from 2003 through 2010, this study examines differences in individual health markers used to calculate allostatic load, with particular attention given to stratification by race/ethnicity and educational level.MethodsFactor analysis with maximum likelihood estimation was used. Fisher's r to z transformation test was used to determine whether or not observed differences in factor loadings were statistically significant.ResultsThe findings reveal the unidimensionality of the concept of allostatic load and the underlying differences in associations between individual biomarkers and summary measures of allostatic load. Additionally, metabolic processes tend to be the most important predictor of allostatic load for all adults; however, inflammatory measures are more important in determining allostatic load scores for non-Hispanic blacks compared to non-Hispanic whites and for adults with less than a college education compared to adults with some college or a college degree.ConclusionsThese findings highlight the continued importance of studying the concept of weathering or allostatic load at the population level and need to better understand how population groups facing exclusion from economic, social, and political power may internalize this position which may cause early health deterioration and ultimate mortality chance through different expression of health insults and premature aging. Am. J. Hum. Biol. 28:627-635, 2016. (c) 2016 Wiley Periodicals, Inc.