Changes in bone architecture in the femoral head and neck in osteoarthritis
Changes in bone architecture in the femoral head and neck in osteoarthritis
复制标题
骨关节炎中股骨头和颈骨结构的变化
DOI：
10.1002/ca.10177
复制
发表时间：
2004
期刊：
影响因子：
2.4
通讯作者：
S. Mcdonald
中科院分区：
文献类型：
--
作者：
M. Neilson;Andrew White;Uzma Malik;E. Morrison;P. McGill;S. Mcdonald
本研究分析了骨关节炎股骨头和股骨颈的骨结构变化。从接受全髋关节置换术的女性患者中获得5个骨关节炎髋关节，并与来自解剖室的非关节炎对照样本进行比较。对股骨头的冠状骨切片和上股骨颈的横截面进行分析。结果表明，在骨关节炎标本中，在压缩性骨小梁区域，骨小梁间面积普遍较小，股骨颈皮质下部增厚。因此，我们的数据量化的变化与其他人报告的压缩性骨小梁增厚和股骨颈区域的增厚一致。我们发现骨关节炎样本中股骨头下部非承重区域和上颈部髓质中的骨小梁较少，与拉伸骨小梁丢失一致。扫描电子显微镜检查表明，骨关节炎股骨头的软骨下和非承重区域的骨吸收活性高于对照组。临床解剖学17：378-391，2004。© 2004 Wiley利斯公司
This study analyses changes in the bony architecture of the femoral head and neck in osteoarthritis. Five osteoarthritic hips were obtained from female patients undergoing total hip replacement and were compared to non‐arthritic control specimens from the dissecting room. Analysis was carried out on a coronal bony slice of the femoral head and on a transverse section of the upper femoral neck. The results indicated that in the region of the compressive trabeculae the intertrabecular areas were generally smaller in the osteoarthritic specimens and that the inferior part of the cortex of the femoral neck had thickened. Our data thus quantified changes consistent with the thickening of compressive trabeculae reported by others and with thickening of the region of the femoral neck on which they converge. We found less trabecular bone in non‐weight‐bearing regions of the lower femoral head and in the medulla of the upper neck in the osteoarthritic specimens consistent with loss of tensile trabeculae. Scanning electron microscopy suggested that bone resorption activity was higher in the subchondral and non‐weight‐bearing regions of the osteoarthritic femoral heads than in the controls. Clin. Anat. 17:378–391, 2004. © 2004 Wiley‐Liss, Inc.