Bioorganic studies on marine natural products--diverse chemical structures and bioactivities.
Bioorganic studies on marine natural products--diverse chemical structures and bioactivities.
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DOI：
10.1002/tcr.20087
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发表时间：
2006
期刊：
影响因子：
6.6
通讯作者：
D. Uemura
中科院分区：
文献类型：
--
作者：
D. Uemura
新分子的发现有助于基本科学概念的发展，产生有价值的药物化合物，并提出可能的新药理学试剂。新发现的物质甚至可以创造新的科学领域。由于海洋生物的栖息地截然不同，已经分离出一些来自海洋生物的次生代谢物的著名例子。这些化合物最显着的两个特性是它们的结构和生理多样性。这些生物活性化合物是用于生理学研究的药物或生物探针的候选者。海藻毒素是一种多元醇化合物，具有极强的急性毒性。软海绵素是来自海绵的显着抗肿瘤大环内酯类化合物。 Pinnatoxins 是一种强效贝类毒素，会导致食物中毒。本文描述了对这些新发现的自然奇观的生物有机研究。还描述了几种生物活性海洋生物碱和动态生态系统中涉及的重要物质。
The discovery of new molecules contributes to the development of basic scientific concepts, leads to valuable drug-oriented compounds, and suggests possible new pharmacological reagents. Newly discovered substances can even be responsible for the creation of new scientific fields. Due to the radically different habitats of marine organisms, several notable examples of secondary metabolites from marine organisms have been isolated. Two of the most remarkable properties of these compounds are their structural and physiological diversities. These bioactive compounds are candidates for drugs or biological probes for physiological studies. Palytoxin is a polyol compound that shows extreme acute toxicity. Halichondrins are remarkable antitumor macrolides from sponge. Pinnatoxins, potent shellfish poisons, cause food poisoning. This paper describes bioorganic studies on such newly discovered wonders of nature. Several bioactive marine alkaloids and important substances involved in dynamic ecological systems are also described.