Dealing with the family: CD147 interactions with cyclophilins.
Dealing with the family: CD147 interactions with cyclophilins.
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DOI：
10.1111/j.1365-2567.2005.02316.x
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发表时间：
2006-03
期刊：
影响因子：
6.4
通讯作者：
Bukrinsky M
中科院分区：
文献类型：
--
作者：
Yurchenko V;Constant S;Bukrinsky M
CD147是一种广泛表达的质膜蛋白，与多种生理和病理活动有关。它以其作为细胞外基质金属蛋白酶诱导剂的功能而闻名（因此该蛋白质的另一个名称是 EMMPRIN），但也已被证明可以调节淋巴细胞反应性、单羧酸转运蛋白表达和精子发生。这些功能反映了 CD147 的多个相互作用的伙伴。最近，CD147 与亲环蛋白家族蛋白的相互作用已得到证实，并且 CD147 作为细胞外亲环蛋白 A 和 B 的信号传导受体的活性已被证明。鉴于细胞外亲环蛋白是各种免疫细胞的有效趋化剂，随后进一步研究了亲环蛋白-CD147相互作用在炎症中的作用。他们证明，针对 CD147 或亲环蛋白的药物在急性或慢性肺病和类风湿性关节炎的动物模型中具有显着的抗炎作用。在这里，我们回顾了有关 CD147 和亲环蛋白之间相互作用的当前知识。
CD147 is a widely expressed plasma membrane protein that has been implicated in a variety of physiological and pathological activities. It is best known for its ability to function as extracellular matrix metalloproteinase inducer (hence the other name for this protein, EMMPRIN), but has also been shown to regulate lymphocyte responsiveness, monocarboxylate transporter expression and spermatogenesis. These functions reflect multiple interacting partners of CD147. Recently, interaction of CD147 with proteins of the cyclophilin family has been demonstrated and activity of CD147 as a signalling receptor to extarcellular cyclophilins A and B has been shown. Given that extracellular cyclophilins are potent chemotactic agents for various immune cells, further studies of the role of cyclophilin–CD147 interaction in inflammation followed. They demonstrated that agents targeting CD147 or cyclophilin had a significant anti-inflammatory effect in animal models of acute or chronic lung diseases and rheumatoid arthritis. Here, we review the current knowledge about interactions between CD147 and cyclophilins.
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DOI：
10.1165/ajrcmb.25.6.4558f
发表时间：
2001-12-01
影响因子：
6.4
作者：
Foda, HD;Rollo, EE;Zucker, S
通讯作者：
Zucker, S
影响因子：
6.5
作者：
DeCastro, R;Zhang, Y;Biswas, C
通讯作者：
Biswas, C
影响因子：
20.3
作者：
Cho, JY;Fox, DA;Chain, B
通讯作者：
Chain, B
影响因子：
64.5
作者：
COLLEY, NJ;BAKER, EK;ZUKER, CS
通讯作者：
ZUKER, CS
影响因子：
4.4
作者：
Arora, K;Gwinn, WM;Constant, SL
通讯作者：
Constant, SL