THE INCIDENCE OF AMYLOIDOSIS COMPLICATING INFLAMMATORY BOWEL-DISEASE - A PROSPECTIVE SURVEY OF 177 PATIENTS
THE INCIDENCE OF AMYLOIDOSIS COMPLICATING INFLAMMATORY BOWEL-DISEASE - A PROSPECTIVE SURVEY OF 177 PATIENTS
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DOI：
10.1007/bf02554129
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发表时间：
1986-05-01
影响因子：
3.9
通讯作者：
PARKINS, RA
中科院分区：
文献类型：
--
作者：
LOWDELL, CP;SHOUSHA, S;PARKINS, RA
报告了3例继发性淀粉样变性，2例患者明确患有克罗恩病，1例患者临床病程为克罗恩病，但组织学检查结果更提示溃疡性结肠炎。所有患者均有肾衰竭的证据。对177例病程超过5年的炎症性肠病患者进行了一项前瞻性研究，试图通过直肠活检和简单的肾功能检查来确定继发性淀粉样变性的发病率。没有发现新的病例，也没有其他情况导致肾衰竭的证据。在没有肾功能不全的情况下，对继发性淀粉样变性的研究可能是不合理的。
Three cases of secondary amyloidosis are reported, two in patients who had unequivocal Crohn''s disease and one in whom the clinical course was that of Crohn''s diseae, but with histologic findings that were more suggestive of ulcerative colitis. All had evidence of renal failure. A prospective study of 177 patients with inflammatory bowel disease of greater than five years'' duration was carried out in an attempt to establish the incidence of secondary amyloidosis, using rectal biopsy and simple renal function tests. No new cases were found. Neither was there evidence of renal failure due to other conditions. In the abence of renal dysfunction, a research for secondary amyloidosis probably is not justified.