In renal hypertension, Cirsium japonicum strengthens cardiac function via the intermedin/nitric oxide pathway
In renal hypertension, Cirsium japonicum strengthens cardiac function via the intermedin/nitric oxide pathway
复制标题
在肾性高血压中，大蓟通过中间体/一氧化氮途径增强心脏功能
DOI：
10.1016/j.biopha.2018.02.126
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发表时间：
2018-05-01
影响因子：
7.5
通讯作者：
Jiang, Yideng
中科院分区：
文献类型：
--
作者：
Yang, Xiaoling;Shao, Hui;Jiang, Yideng
大蓟是传统中药的一种成分，已被证明具有抗炎作用，并能改善循环，从而消除血液淤滞。研究表明，中介素（intermedin，IMD）通过调节血管紧张素/一氧化氮（Ang/NO）代谢途径对大鼠高血压具有保护作用。在这项研究中，我们研究是否通过调节IMD的表达，大蓟可以改善2k 1c诱导的肾性高血压大鼠的心功能。通过阻塞肾动脉在Sprague-Dawley大鼠中诱导肾性高血压。将大鼠随机分为假手术组、2k 1c组、2k 1c+大蓟组（1.8g/kg·d）和2k 1c + IMD组（n = 10）。检测心功能、血浆血管紧张素II（Ang II）、IMD、血清一氧化氮（NO）、一氧化氮合酶（NOS）水平以及主动脉和左心室IMD、肾上腺髓质素（ADM）的表达。大蓟或IMD的管理显着加强心功能在2k 1c诱导的大鼠，增加血清NO和NOS水平，降低血浆血管紧张素II，并上调IMD在主动脉和左心室的表达。这些结果表明大蓟通过IMD/NO通路对2k 1c诱导的大鼠肾性高血压具有心脏保护作用。
Cirsium japonicum, a constituent of traditional Chinese medicine, has been shown to exert inflammatory effects as well as to improve the circulation and thus to counteract hematologic stasis. Studies have demonstrated that intermedin (IMD) has protective effects on hypertension in rats by regulating the Ang/NO metabolic pathway. In this study, we investigated whether by regulating the expression of IMD, Cirsium japonicum could improve cardiac function in rats with 2k1c-induced renal hypertension. Renal hypertension was induced in Sprague-Dawley rats by occluding the renal artery. The rats were maintained on a normal diet and randomly divided into four groups: sham, 2k1c, 2k1c with Cirsium japonicum (1.8 g/kg per day) and 2k1c with IMD (n = 10 in each group). Cardiac function, plasma angiotensin II (Ang II), IMD, serum nitric oxide (NO) and nitric oxide synthase (NOS), as well as the expression of IMD and adrenomedullin (ADM) in the aorta and left ventricle were analyzed. Administration of Cirsium japonicum or IMD significantly strengthened cardiac function in 2k1c-induced rats, increased serum NO and NOS levels, reduced plasma Ang II, and upregulated IMD expression in the aorta and left ventricle. These results demonstrate that Cirsium japonicum has cardioprotective effects on 2k1c-induced renal hypertension in rats via the IMD/NO pathway.