Postnatal maturation of vagal respiratory reflexes in preterm and full-term lambs
Postnatal maturation of vagal respiratory reflexes in preterm and full-term lambs
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DOI：
10.1152/japplphysiol.00480.2002
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发表时间：
2003-05-01
影响因子：
3.3
通讯作者：
Praud, JP
中科院分区：
文献类型：
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作者：
Arsenault, J;Moreau-Bussière, F;Praud, JP
对早产羔羊和足月羔羊的呼吸反射起源于支气管肺受体的出生后发育进行了评估。对10只早产羔羊(胎龄132天)和7只没有镇静的足月羔羊从第1天到第42天重复测量通气量和动脉压。Hering-Breuer抑制反射(缓慢适应伸展感受器)通过吸气末阻塞时呼气时间的增加来评估。用初始呼吸暂停+心动过缓+全身性低血压和静脉注射辣椒素后继发性呼吸急促来评估肺化学反射(C纤维终末)。研究结果表明：1)早产并不影响Hering-Breuer反射的成熟。2)早产羔羊在出生后最初几个小时出现典型的肺化学反射，而这种反射的快速呼吸成分在出生后第1天比足月羔羊弱。3)早产导致这种快速呼吸反应的出生后成熟逆转(有随出生年龄增加的趋势)。我们的发现表明，羔羊的早产改变了出生后肺化学反射的成熟。
The postnatal development of ventilatory reflexes originating from bronchopulmonary receptors was assessed in preterm vs. full-term lambs. Ventilation and arterial pressure were repeatedly measured in 10 preterm ( gestational age, 132 days) and 7 full-term lambs without sedation from day 1 to day 42. The Hering-Breuer inhibitory reflex ( slowly adapting stretch receptors) was assessed by the increase in expiratory time during end-inspiratory occlusion. The pulmonary chemoreflex (C-fiber endings) was assessed by the initial apnea + bradycardia + systemic hypotension and the secondary tachypnea after capsaicin intravenous injection. Results show the following. 1) Premature birth did not modify the maturation of the Hering-Breuer reflex. 2) Whereas a classic pulmonary chemoreflex was observed in the very first hours of life in preterm lambs, the tachypneic component of this reflex was weaker than in full-term lambs on day 1. 3) Premature birth led to a reversed postnatal maturation of this tachypneic response ( tendency to increase with postnatal age). Our findings suggest that premature birth in lambs modifies postnatal maturation of the pulmonary chemoreflex.