Plant receptor kinases: Systemin receptor identified
Plant receptor kinases: Systemin receptor identified
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DOI：
10.1073/pnas.152330799
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发表时间：
2002-07
影响因子：
11.1
通讯作者：
Yanhai Yin;Dongying Wu;J. Chory
中科院分区：
文献类型：
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作者：
Yanhai Yin;Dongying Wu;J. Chory
植物的生长和发育受内在生长调节因子以及有益和有害的环境因素的调节。激素、环境或病原信号主要由膜定位的受体感知，这些受体将这些信号传递到植物细胞内，以激活指导生长、发育和防御反应的程序。在完全测序的拟南芥基因组中（1），有超过600个受体样激酶（RLK）基因，其中约200个属于称为富含亮氨酸重复序列（LRR）受体样激酶（LRR-RLKs;参考文献2）的家族。LRR-RLKs的主要特征是其胞外结构域和胞内蛋白激酶结构域，胞外结构域由高度保守的富含亮氨酸基序的串联重复序列组成，胞内蛋白激酶结构域具有Ser/Thr特异性。LRR通常参与蛋白质-蛋白质相互作用，因此被认为在配体结合中起作用（3）。尽管植物中存在大量LRR-RLKs，但其中只有不到10种具有已知的生物学功能。对于那些已知一些功能的LRR-RLKs，LRR-RLKs在不同的过程中发挥作用，如激素感知，分生组织信号传导和病原体反应（2）。甚至更少的LRR-RLK具有已知的配体。在本期PNAS中，SR 160，一种番茄LRR-RLK，已被鉴定为系统素的受体，系统素是一种参与系统性创伤信号传导的肽（4）。
Plant growth and development are regulated by intrinsic growth regulators, as well as by both beneficial and detrimental environmental cues. Hormonal, environmental, or pathogenic signals are mostly perceived by membrane-localized receptors that transduce those signals inside plant cells to activate programs directing growth, development, and defense responses. In the fully sequenced Arabidopsis genome (1), there are more than 600 receptor-like kinase (RLK) genes, about 200 of which belong to a family called leucine-rich repeat (LRR) receptor-like kinases (LRR-RLKs; ref. 2). The main characteristics of LRR-RLKs are their extracellular domains which are composed of tandem repeats of a well conserved leucine-rich motif and intracellular protein kinase domains with Ser/Thr specificity. LRRs often participate in protein–protein interactions and, therefore, are believed to function in ligand binding (3). Despite the large numbers of LRR-RLKs in plants, fewer than 10 of them have known biological functions. For those about which some function is known, the LRR-RLKs play a role in diverse processes such as hormone perception, meristem signaling, and pathogen responses (2). Even fewer LRR-RLKs have known ligands. In this issue of PNAS, SR160, a tomato LRR-RLK, has been identified as the receptor for systemin, a peptide involved in systemic wounding signaling (4).