MANOMETRIC EVALUATION OF FUNCTIONAL UPPER GUT SYMPTOMS
MANOMETRIC EVALUATION OF FUNCTIONAL UPPER GUT SYMPTOMS
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DOI：
10.1016/s0016-5085(85)80083-4
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发表时间：
1985-01-01
期刊：
影响因子：
29.4
通讯作者：
STANGHELLINI, V
中科院分区：
文献类型：
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作者：
MALAGELADA, JR;STANGHELLINI, V
在转诊至马约诊所[USA]的104例患者中研究了胃和上肠的压力活动，以评价功能性症状（恶心、呕吐、上腹痛或其他消化不良症状，但无结构性肠道异常）。在75例患者中发现测压异常。其中43例患者有胃异常，32例患者有胃和肠道异常。在胃中，固体餐后胃窦相位压活动降低是最常见的异常。在上肠，非传播爆发的阶段性和紧张性收缩活动是一个相对频繁的异常，但也观察到一些其他改变测压模式。消化道症状不是胃肠道测压异常的存在或部位的良好预测因子。患有相关神经系统、泌尿系统或代谢（糖尿病）疾病的患者比那些没有肠道外疾病证据的患者更容易表现出测压异常。几乎三分之二有症状且测压正常的患者表现出提示精神疾病的特征。在有严重功能型症状的患者中，胃肠道测压是一种有用的技术，可以证明这些患者中相对较高比例存在潜在的肠道运动障碍。
Pressure activity in the stomach and upper intestine was studied in 104 patients referred to the Mayo Clinic [USA] for evaluation of functional symptoms (nausea, vomiting, upper abdominal pain or other dyspeptic symptoms in the absence of structural gut abnormalities). Manometric abnormalities were found in 75 patients. Of these 43 had gastric abnormalities and 32 patients had both gastric and intestinal abnormalities. In the stomach, decreased antral phasic pressure activity after a solid meal was the most common abnormality. In the upper intestine, unpropagated bursts of phasic and tonic contractile activity were a relatively frequent abnormality but a number of other altered manometric patterns also were observed. Digestive tract symptoms were not good predictors of the presence or site of the gastrointestinal manometric abnormalities. Patients with associated neurologic, urologic or metabolic (diabetes) disease were more likely to exhibit manometric abnormalities than were those without evidence of disease outside the gut. Almost two-thirds of the patients with symptoms and normal manometry presented features suggestive of psychiatric disease. In patients with severe functional-type symptoms gastrointestinal manometry is a useful technique to evidence the underlying gut motor disturbance that is present in a relatively high proportion of these patients.