Responses of human clasp and sling fibers to neuromimetics
Responses of human clasp and sling fibers to neuromimetics
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DOI：
10.1111/j.1440-1746.2003.03307.x
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发表时间：
2004-04-01
影响因子：
4.1
通讯作者：
Zhang, YF
中科院分区：
文献类型：
--
作者：
Tian, ZQ;Liu, JF;Zhang, YF
背景和目的：以前已经证明，人类胃食管交界处的扣和吊带纤维对乙酰胆碱（Ach）的反应不同。本研究旨在探讨两种肌肉纤维的生理和药理特性之间的差异。方法：记录人体吊带和扣环纤维对乙酰胆碱、多巴胺（DA）、苯肾上腺素（Phe）和异丙肾上腺素（Iso）等张力的反应。这些标本取自18例食管癌手术患者。结果：乙酰胆碱和苯丙氨酸均能增加两种肌肉的张力；乙酰胆碱组的张力值是苯丙氨酸组的3-4倍，而Iso则降低了两种肌肉条的张力。低浓度DA可降低吊索纤维张力，然后随着浓度的增加逐渐升高。相反，当DA浓度较低时，卡扣纤维的张力变化不明显，但随着DA浓度的增加，张力缓慢升高。结论：环扣纤维和吊带纤维对各种药物的敏感性和最大反应不同。这表明这两种纤维在建立食管下括约肌张力方面具有不同的作用，这对该区域疾病的内科和外科治疗具有重要意义。(C) 2004 Blackwell出版亚洲有限公司
Background and Aims: It has previously been demonstrated that clasp and sling fibers at the human gastroesophageal junction respond differently to acetylcholine (Ach). The present study was undertaken to investigate the differences between the physiological and pharmacological properties of the two types of muscle fiber.Methods: Recordings were made of the isometric tension of human sling and clasp fibers in response to Ach, dopamine (DA), phenylephrine (Phe), and isoprenaline (Iso). These specimens were obtained from 18 patients who were operated on for esophageal cancer.Results: Both Ach and Phe increased the tension of the two types of muscle; the values in the Ach group being 3-4-fold greater than those in the Phe group, while Iso decreased the tension of both types of muscle strip. The tension of the sling fibers was reduced by DA at lower concentration, and then increased gradually as the concentration was increased. In contrast, the tension of the clasp fibers did not obviously change when the concentration of DA was lower, but a slow elevation of tension was seen with the increase in DA concentration.Conclusions: The sensitivities and maximum responses to each agent differed between the clasp fibers and sling fibers. This suggests that the two kinds of fiber have different roles in establishing tension in the lower esophageal sphincter, with implications for the medical and surgical treatment of disorders in this region. (C) 2004 Blackwell Publishing Asia Pty Ltd.