Serum levels of oxidative stress as a marker of disease severity in idiopathic pulmonary fibrosis
Serum levels of oxidative stress as a marker of disease severity in idiopathic pulmonary fibrosis
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DOI：
10.1016/j.pupt.2006.10.005
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Gourgoulianis, Konstantinos I.
中科院分区：
文献类型：
--
作者：
Daniil, Zoe D.;Papageorgiou, Evangelia;Gourgoulianis, Konstantinos I.
背景资料：特发性肺纤维化（IPF）是一种以进行性纤维化为特征的致死性疾病，导致严重呼吸困难和肺功能受损。虽然肺纤维化发生的机制尚未完全确定，但最近的研究结果表明，氧化应激可能在组织纤维化的发病机制中发挥重要作用。目的：评价IPF患者血清中的氧化应激水平，探讨氧化应激水平与呼吸困难和肺功能损害之间的关系。材料和方法：分析了2年内连续招募的21例未经治疗的IPF患者和12例对照的血液样本。通过分光光度法（D-ROM试验）测定血液中的氧化应激水平。测定FVC和DLCO。结果：IPF患者的血清氧化应激水平显著高于对照组（平均值± SEM：356.8 ± 14和201 ± 10 Carratelli单位，p <0.05），而对照组的血清氧化应激水平显著高于对照组（平均值± SEM：356.8 ± 14和201 ± 10 Carratelli单位，p <0.05）。
Background: Idiopathic Pulmonary fibrosis (IPF) is a fatal illness characterized by progressive fibrosis resulting in severe dyspnea and impairment Of lung function. Although the mechanisms by which lung fibrosis develops are not fully ascertained, recent findings suggest that oxidative stress may play an important role in the pathogenesis of tissue fibrosis.Aim: To evaluate the oxidative stress in the serum of patients with IPF and to explore the relationship between oxidative stress levels, dyspnea and impairment of lung function.Material and methods: Blood samples from 21 untreated patients with IPF, sequentially recruited over a period of 2 years, and 12 controls were analyzed. The level of oxidative stress in the blood was determined through a spectrophotometric procedure (D-ROMs test). FVC and DLCO were measured in all patients. The level of dyspnea was assessed by the Medical Research Council (MRC) chronic dyspnea scale.Results: Serum levels of oxidative stress were significantly increased in patients with IPF compared to controls (mean +/- SEM: 356.8 +/- 14 and 201 +/- 10 Carratelli units respectively, p