SMART: a web-based tool for the study of genetically mobile domains
SMART: a web-based tool for the study of genetically mobile domains
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DOI：
10.1093/nar/28.1.231
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发表时间：
2000-01-01
影响因子：
14.9
通讯作者：
Bork, P
中科院分区：
文献类型：
--
作者：
Schultz, J;Copley, RR;Bork, P
SMART（一个简单的模块化架构研究工具）允许识别和注释遗传移动的域和分析域架构（SMART.embl-heidelberg.de）。在信号传导、细胞外和染色质相关蛋白中发现的400多个结构域家族是可检测的。这些结构域的系统分布，功能类，三级结构和功能上重要的残基进行了广泛的注释。在非冗余蛋白质数据库中发现的每个结构域以及搜索参数和分类信息存储在关系数据库系统中，该数据库的用户界面允许搜索包含定义的分类群中的结构域的特定组合的蛋白质。
SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures (http://SMART.embl-heidelberg.de). More than 400 domain families found in signalling, extracellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system, User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa.