Self-assembled nanodiamond supraparticles for anticancer chemotherapy
Self-assembled nanodiamond supraparticles for anticancer chemotherapy
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DOI：
10.1039/c8nr00641e
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发表时间：
2018-05-21
期刊：
影响因子：
6.7
通讯作者：
Miyako, Eijiro
中科院分区：
文献类型：
--
作者：
Yu, Yue;Nishikawa, Masahiro;Miyako, Eijiro
纳米金刚石（ND）由于其相对较低的成本、适合大规模合成、独特的结构和低毒性，是一种有前途的药物输送应用材料。然而，合成具有均匀且可调的尺寸、高负载能力、药物递送功效以及表面功能化方面的多功能性的载药ND缀合物一直具有挑战性。在这里，我们证明全氟辛酸功能化的 ND 会自发转化为分散良好且生物相容的超颗粒（SP）纳米团簇。我们证明，合成的基于 ND 的 SP (ND-SP) 对细胞膜具有高渗透性，因此非常适合作为传统纳米药物的药物载体，例如聚乙二醇和磷脂基纳米胶囊以及简单的载药 ND 缀合物。我们证实了 ND-SP 在体外和体内消灭癌细胞的功效。我们的结果表明，合成的 ND-SP 可用于多种生物应用中的靶向药物递送。
A nanodiamond (ND) is a promising material for drug delivery applications owing to its relatively low cost, amenability to large-scale synthesis, unique structure, and low toxicity. However, synthesizing drug-loaded ND conjugates with uniform and tunable sizes, high loading capacity, efficacy in drug delivery, and versatility in terms of surface functionalization has been challenging. Here, we show that perfluorooctanoic acid-functionalized NDs spontaneously transform into well-dispersed and biocompatible supraparticle (SP) nanoclusters. We demonstrate that the synthesized ND-based SPs (ND-SPs) exhibit high penetration through the cell membrane and are therefore superior as drug carriers for conventional nanomedicines such as polyethylene glycol and phospholipid-based nanocapsules and simple drug-loaded ND conjugates. We confirm the efficacy of ND-SPs in the eradication of cancer cells in vitro and in vivo. Our results demonstrate that the synthesized ND-SPs are useful for targeted drug delivery in a variety of biological applications.