Configuration of the psymberin amide side chain
Configuration of the psymberin amide side chain
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DOI：
10.1021/ol0508375
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发表时间：
2005-07-07
期刊：
影响因子：
5.2
通讯作者：
Williams, LJ
中科院分区：
文献类型：
--
作者：
Kiren, S;Williams, LJ
提出了一种有效的和选择性的细胞毒素Psymberin的酰胺侧链的结构。制备了酰胺侧链的顺式和反式模型，并通过对反式异构体的X射线晶体学分析确认了结构归属。比较H-1和C-13 NMR数据确定了天然产物与反式构型的合成模型化合物之间的同源性，而不是相应的顺式异构体。
The structure of the amide side chain of psymberin, a potent and selective cytotoxin, is proposed. Syn and anti models of the amide side chain were prepared, and the structural assignment was confirmed by X-ray crystallographic analysis of the anti isomer. Comparison of H-1 and C-13 NMR data establishes homology between the natural product and the synthetic model compound of anti configuration and not the corresponding syn isomer.