Leucine7 to proline7 polymorphism in the preproneuropeptide Y is associated with the progression of carotid atherosclerosis, blood pressure and serum lipids in Finnish men
Leucine7 to proline7 polymorphism in the preproneuropeptide Y is associated with the progression of carotid atherosclerosis, blood pressure and serum lipids in Finnish men
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DOI：
10.1016/s0021-9150(01)00468-3
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发表时间：
2001-11-01
期刊：
影响因子：
5.3
通讯作者：
Salonen, JT
中科院分区：
文献类型：
--
作者：
Karvonen, MK;Valkonen, VP;Salonen, JT
欧洲前肽Y （prepro-NPY）基因信号肽中一个相当常见的亮氨酸7-对脯氨酸7 （Leu7Pro）多态性可能在人类血压调节、胆固醇代谢和动脉粥样硬化发病机制中起重要作用。我们研究了芬兰966名42-60岁男性的人群样本中Leu7Pro多态性与颈动脉粥样硬化进展、血压和血脂的关系。Pro7替代（携带者频率12.2%）与平均（P = 0.01）和最大（P = 0.007）颈总内膜-中膜厚度（IMT）的四年加速增长有关，并与收缩压（P = 0.03）和舒张压（P = 0.02）的轻微升高有关，经其他主要危险因素校正后。与Leu7/Leu7基因型男性相比，Pro7基因型男性的平均IMT增加30.6% (95% Cl 6.9-54.0%)，最大IMT增加20.0% （95% CI 5.3-34.4%）。Pro7替代也与肥胖（体重指数（BMI） bbb30 kg/m(2)）男性血清总胆固醇（P = 0.01）和低密度脂蛋白胆固醇（P = 0.02）升高有关。这项研究提供了重要的证据，表明pre - pro- npy中的Pro7取代是人类动脉粥样硬化加速进展、血压升高和血清胆固醇升高的重要危险因素。(C) 2001爱思唯尔科学爱尔兰有限公司版权所有。
A rather common leucine7-to-proline7 (Leu7Pro) polymorphism in the preproneuropeptide Y (prepro-NPY) gene signal peptide may be important in blood pressure regulation, cholesterol metabolism and the pathogenesis of atherosclerosis in humans. We examined the associations of the Leu7Pro polymorphism with carotid atherosclerotic progression, blood pressure and serum lipids in a population-based sample of 966 men aged 42-60 years in Finland. The Pro7 substitution (carrier frequency 12.2%) was associated with accelerated four-year increase in the mean (P = 0.01) and maximal (P = 0.007) common carotid intima-media thickness (IMT) and with slightly increased systolic (P = 0.03) and diastolic (P = 0.02) blood pressures, adjusted for other major risk factors. Men with Pro7 substitution had 30.6% (95% Cl 6.9-54.0%) greater increase in the mean IMT and 20.0% (95% CI 5.3-34.4%) greater increase in the maximal IMT than men with Leu7/Leu7 genotype. The Pro7 substitution was also related to increased serum total cholesterol (P = 0.01) and LDL cholesterol (P = 0.02) in obese (body mass index (BMI) > 30 kg/m(2)) men. This study provides important evidence suggesting that the Pro7 substitution in the prepro-NPY is an important risk factor for accelerated atherosclerotic progression, increased blood pressure and increased serum cholesterol in humans. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.