MR imaging of murine arthritis using ultrasmall superparamagnetic iron oxide particles
MR imaging of murine arthritis using ultrasmall superparamagnetic iron oxide particles
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DOI：
10.1016/s0730-725x(01)00448-9
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发表时间：
2001-11-01
影响因子：
2.5
通讯作者：
Hirsch, R
中科院分区：
文献类型：
--
作者：
Dardzinski, BJ;Schmithorst, VJ;Hirsch, R
这项工作的目的是确定超小超顺磁性氧化铁（USPIO）颗粒的磁共振（MR）成像的能力，以提供定量措施的炎症在自身免疫性arthritis.Mice静脉注射或关节内注射USPIO，然后通过磁共振和膝关节的组织学评估。比较了未经处理的小鼠和胶原诱导的关节炎小鼠的MR显微图像和组织学。静脉给药后，在腘淋巴结中观察到USPIO蓄积，但在关节中未观察到。关节内注射USPIO导致关节信号丢失。磁共振信号强度可以量化，并与铁染色的滑膜衬里。与未处理小鼠相比，在关节炎小鼠中观察到USPIO摄取的显著增加和信号强度的相应降低。这些研究为USPIO在关节炎中的临床应用提供了依据，以评估疾病的严重程度和监测对治疗的反应。(C)2001 Elsevier Science Inc. All rights reserved.
The objective of this work was to determine the ability of magnetic resonance (MR) imaging with ultrasmall superparamagnetic iron oxide (USPIO) particles to provide quantitative measures of inflammation in autoimmune arthritis.Mice were injected intravenously or intra-articularly with USPIO followed by magnetic resonance and histological assessment of the knee joint. Comparisons were made between MR microimages and histology in naive mice and mice with collagen-induced arthritis.Following intravenous administration, accumulation of USPIO was observed in the popliteal lymph nodes, but not the joint. Administration of USPIO intra-articularly resulted in signal loss in the joint. The MR signal intensity could be quantified and correlated with iron staining in the synovial lining. A marked increase in USPIO uptake and a corresponding decrease in signal intensity were observed in arthritic, compared to naive mice. Areas of focal signal loss corresponded to foci of iron staining by histology.These studies may provide a basis for the clinical application of USPIO in arthritis for assessing disease severity and monitoring response to therapy. (C) 2001 Elsevier Science Inc. All rights reserved.