MULTIPLE REPRESENTATIONS OF PAIN IN HUMAN CEREBRAL-CORTEX
MULTIPLE REPRESENTATIONS OF PAIN IN HUMAN CEREBRAL-CORTEX
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DOI：
10.1126/science.2003220
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发表时间：
1991-03-15
期刊：
影响因子：
56.9
通讯作者：
DUNCAN, GH
中科院分区：
文献类型：
--
作者：
TALBOT, JD;MARRETT, S;DUNCAN, GH
疼痛在大脑皮层中的表征比任何其他感觉系统都更难理解。然而，随着磁共振成像和正电子发射断层扫描在人类中的使用，现在已经证明，疼痛的热量会导致对侧前扣带回，次级躯体感觉和初级躯体感觉皮层的显着激活。这与在类似实验中由振动触觉刺激引起的初级躯体感觉皮层的主要激活形成对比。此外，单侧扣带回激活表明，这个被认为调节情绪的前脑区域包含意想不到的特定疼痛表现。
The representation of pain in the cerebral cortex is less well understood than that of any other sensory system. However, with the use of magnetic resonance imaging and positron emission tomography in humans, it has now been demonstrated that painful heat causes significant activation of the contralateral anterior cingulate, secondary somatosensory, and primary somatosensory cortices. This contrasts with the predominant activation of primary somatosensory cortex caused by vibrotactile stimuli in similar experiments. Furthermore, the unilateral cingulate activation indicates that this forebrain area, thought to regulate emotions, contains an unexpectedly specific representation of pain.