Serum relaxin levels are reduced in pregnant women with a history of recurrent miscarriage, and correlate with maternal uterine artery Doppler indices in first trimester
Serum relaxin levels are reduced in pregnant women with a history of recurrent miscarriage, and correlate with maternal uterine artery Doppler indices in first trimester
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DOI：
10.1016/j.ejogrb.2009.07.008
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发表时间：
2009-11-01
影响因子：
2.6
通讯作者：
Li, Tin C.
中科院分区：
文献类型：
--
作者：
Anumba, Dilly O. C.;El Gelany, Saad;Li, Tin C.
目的：着床缺陷是复发性流产（RPL）的一种机制。我们试图确定有 RPL 病史的女性中人松弛素 2 (RLX) 的血清表达是否受损。 研究设计：采用前瞻性病例对照设计，我们研究了 20 名有 RPL 病史的孕妇和 20 名无 RPL 病史的年龄匹配的女性 (NRPL)。我们在 6-8 点通过 ELISA 测量了血清松弛素 2 水平。妊娠 10-12、20 和 34 周以及脐带血中，以及妊娠 >= 10 周时的母体子宫动脉多普勒阻力指数 (RI)。结果：松弛素在 12 周时上升到峰值，并在接近足月时逐渐下降。在所有妊娠期间，有 RPL 病史的女性的 RLX 水平低于没有 RPL 病史的女性。妊娠 10-12 周时，子宫动脉 RI 与 RPL 和 NRPL 的血清 RLX 相关。在 10-12 周的 NRPL 组中，存在缺口波形与不存在缺口波形相比，与更高的 RLX 水平相关（平均 2.1 ng/ml vs. 1.3 ng/ml，P < 0.05），并且在 20 周时也是如此（2.1 ng/ml vs. 0.95 ng/ml，P < 0.05），但在 RPL 组中没有看到这种差异。 RPL 组的脐静脉 RLX 比 NRPL 组高 4 倍。结论：有 RPL 病史的女性在所有妊娠三个月期间血清 RLX 水平均减弱。 RLX 代谢失调如何导致 RPL 不良妊娠结局需要进一步研究。 Crown 版权所有 (C) 2009 由 Elsevier Ireland Ltd 出版。保留所有权利。
Objectives: Defective implantation is a mechanism for recurrent pregnancy loss (RPL). We sought to determine whether the serum expression of human relaxin-2 (RLX) is impaired in women with a history of RPL.Study design: Employing a prospective case-controlled design we studied 20 pregnant women with a history of RPL and 20 age-matched women with no history of RPL (NRPL). We measured serum relaxin-2 levels by ELISA at 6-8. 10-12, 20, and 34 weeks gestation and in cord blood, and maternal uterine artery Doppler resistance index (RI) at >= 10 weeks gestation.Results: Relaxin rose to a peak at 12 weeks, and gradually declined towards term. At all gestations, women with a history of RPL had lower RLX levels than women without. At 10-12 weeks gestation, uterine artery RI correlated with serum RLX for both RPL and NRPL. In the NRPL group at 10-12 weeks the presence of a notched waveform was associated with higher RLX levels than the absence of a notch (mean 2.1 ng/ml vs. 1.3 ng/ml, P < 0.05) and also at 20 weeks (2.1 ng/ml vs. 0.95 ng/ml, P < 0.05) but no such difference was seen in the RPL group. Umbilical venous RLX was 4-fold higher in the RPL group than the NRPL group.Conclusion: Women with a history of RPL demonstrate attenuated levels of serum RLX across all pregnancy trimesters. How dysregulated RLX metabolism may contribute to adverse pregnancy outcome in RPL requires further investigation. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.