Rac Mediates Mouse Spermatogonial Stem Cell Homing to Germline Niches by Regulating Transmigration through the Blood-Testis Barrier
Rac Mediates Mouse Spermatogonial Stem Cell Homing to Germline Niches by Regulating Transmigration through the Blood-Testis Barrier
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DOI：
10.1016/j.stem.2011.08.011
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发表时间：
2011-11-04
期刊：
影响因子：
23.9
通讯作者：
Shinohara, Takashi
中科院分区：
文献类型：
--
作者：
Takashima, Seiji;Kanatsu-Shinohara, Mito;Shinohara, Takashi
精原干细胞(SSCs)的归巢能力允许它们在移植到不育的睾丸后迁移到壁龛中。移植的SSCs附着在Sertoli细胞上，通过Sertoli间紧密连接形成的血-睾丸屏障(BTB)向基底膜上的壁龛迁移。最关键的一步是通过BTB，这将寻的效率限制在
The homing ability of spermatogonial stem cells (SSCs) allows them to migrate into niches after being transplantated into infertile testes. Transplanted SSCs attach to Sertoli cells and transmigrate through the blood-testis barrier (BTB), formed by inter-Sertoli tight junctions, toward niches on the basement membrane. The most critical step is the passage through the BTB, which limits the homing efficiency to