Hyperlipidemia as a risk factor of renal allograft function impairment
Hyperlipidemia as a risk factor of renal allograft function impairment
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DOI：
10.1034/j.1399-0012.2001.150108.x
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发表时间：
2001-02-01
影响因子：
2.1
通讯作者：
Soares, V
中科院分区：
文献类型：
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作者：
Carvalho, MFC;Soares, V
在这项研究中，前瞻性比较了患有[高胆固醇组（HCG），n = 30]或不存在[正常胆固醇组（NCG），n = 42]高胆固醇血症以及具有[高甘油三酯组（HTG），n = 33]或不存在[正常甘油三酯组（n = 36]高甘油三酯血症）的同种异体肾移植受者的移植结果。移植后 6 个月时，各组之间（NTG 与 HTG 比较，NCG 与 HCG 比较）在年龄、动脉高血压、供体类型（亲属或尸体）、免疫抑制治疗、每个患者的排斥反应次数、急性细胞排斥患者的频率、糖尿病或蛋白尿> 3 g/24 h 患者的患病率以及平均血清肌酐方面没有观察到显着差异。 NTG 和 HTG 随访期间血清肌酐翻倍的概率存在统计学差异（12 个月：NTG = 0.03，HTG = 0.15；36 个月：NTG = 0.08，HTG = 0.33；60 个月：NTG = 0.08，HTG = 0.48；120 个月：NTG = 0.18，HTG = 0.48），但 NCG 和 HCG 之间不存在差异（12 个月：NCG = 0.05，HCG = 0.13；36 个月：NCG = 0.13，HCG = 0.24；60 个月：NCG = 0.19，HCG = 0.31；84 个月：NCG = 0.27，HCG = 0.31）。 HCG 和 NCG 之间或 NTG 和 HTG 之间的精算移植物存活率没有显着差异。高甘油三酯血症（而非高胆固醇血症）与移植物功能丧失相关。
In this study, the graft outcome in renal allograft recipients with [high cholesterol group (HCG), n = 30] or without [normal cholesterol group (NCG), n = 42] hypercholesterolemia and with [high triglyceride group (HTG), n = 33] or without [normal triglyceride group (NTG), n = 36] hypertriglyceridemia were prospectively compared. At 6 months post-transplantation, no significant difference was observed between the groups (NTG compared with HTG, and NCG compared with HCG) regarding age, presence of arterial hypertension, kind of donor (living related or cadaveric), immunosuppressive therapy, number of rejection episodes per patient, frequency of patients with acute cellular rejection, prevalence of patients with diabetes mellitus or proteinuria > 3 g/24 h, and mean serum creatinine. The probability of doubling serum creatinine during follow-up was statistically different between NTG and HTG (12 months: NTG = 0.03, HTG = 0.15; 36 months: NTG = 0.08, HTG = 0.33; 60 months: NTG = 0.08, HTG = 0.48; and 120 months: NTG = 0.18, HTG = 0.48), but not between NCG and HCG (12 months: NCG = 0.05, HCG = 0.13; 36 months: NCG = 0.13, HCG = 0.24; 60 months: NCG = 0.19, HCG = 0.31; 84 months: NCG = 0.27, HCG = 0.31). There was no significant difference in actuarial graft survival between HCG and NCG or between NTG and HTG. Hypertriglyceridemia, but not hypercholesterolemia, was associated with loss of graft function.