Genetic variation of GRIN1 confers vulnerability to methamphetamine-dependent psychosis in a Thai population
Genetic variation of GRIN1 confers vulnerability to methamphetamine-dependent psychosis in a Thai population
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DOI：
10.1016/j.neulet.2013.07.017
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发表时间：
2013-09-13
影响因子：
2.5
通讯作者：
Nudmamud-Thanoi, Sutisa
中科院分区：
文献类型：
--
作者：
Chanasong, Rachanee;Thanoi, Samur;Nudmamud-Thanoi, Sutisa
GRIN1是一个编码n -甲基- d天冬氨酸（NMDA）受体亚单位1 （NR1）的基因。GRIN1的变异已被确定为精神分裂症和药物依赖的危险因素，支持了这些疾病中谷氨酸能功能障碍的假设。甲基苯丙胺（Methamphetamine，简称冰毒）是一种精神兴奋剂，可诱发精神症状，与精神分裂症类似；因此，GRIN1是甲基苯丙胺依赖或甲基苯丙胺依赖精神病易感性的候选基因。本研究使用PCR-RFLP技术检测了100名泰国男性甲基甲醚依赖患者和103名健康对照者中gr1的两种多态性rs11146020 （G1001C）和rs1126442 （G2108A）。尽管rs1126442与甲基苯丙胺依赖性精神病高度显著相关，但这两种多态性都与甲基苯丙胺依赖性精神病存在显著相关性，其中A等位基因的频率降低(P
GRIN1 is a gene that encodes the N-methyl-D aspartate (NMDA) receptor subunit1 (NR1). Variations of GRIN1 have been identified as a risk factor for schizophrenia and drug dependence, supporting hypotheses of glutamatergic dysfunction in these disorders. Methamphetamine (METH) is a psychostimulant drug which can induce psychotic symptoms reminiscent of those found in schizophrenia; thus GRIN1 is a candidate gene for vulnerability to METH dependence or METH-dependent psychosis. The present study examined two polymorphisms of GRIN1, rs11146020 (G1001C) and rs1126442 (G2108A), in 100 male Thai METH-dependent patients and 103 healthy controls using PCR-RFLP techniques. Neither polymorphism was significantly associated with METH dependence, although rs1126442 was highly significantly associated with METH-dependent psychosis, in which the A allele showed reduced frequency (P