Ultrasmall Fe(III)-Tannic Acid Nanoparticles To Prevent Progression of Atherosclerotic Plaques
Ultrasmall Fe(III)-Tannic Acid Nanoparticles To Prevent Progression of Atherosclerotic Plaques
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DOI：
10.1021/acsami.1c09480
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发表时间：
2021-07-19
影响因子：
9.5
通讯作者：
Zhang, Bing
中科院分区：
文献类型：
--
作者：
Mu, Dan;Wang, Wenshen;Zhang, Bing
巨噬细胞聚集是动脉粥样硬化斑块发病机制的核心。减少斑块中的巨噬细胞是减缓动脉粥样硬化发展的一种有吸引力的方法。化学动力学疗法是在微酸性环境中特异性抑制富含过氧化氢（H2 O2）的细胞的一种治疗肿瘤的新方法。在此，我们制造了超小的多巴胺修饰的透明质酸（HD）稳定的Fe（III）-单宁酸纳米粒子（HFTNP）。HFTNP可以特异性地积聚在动脉粥样硬化斑块中的炎性巨噬细胞中，提供更明亮的磁共振图像，促进活性氧（ROS）的产生，并诱导炎性巨噬细胞的死亡而不损伤正常细胞和组织。总之，HFTNP作为动脉粥样硬化的安全有效的诊断和治疗试剂具有巨大的潜力。
Macrophage accumulation is central to the pathogenesis of atherosclerotic plaques. Reducing macrophages in plaques is an appealing approach to attenuate the development of atherosclerosis. Chemodynamic therapy, specifically inhibiting hydrogen peroxide (H2O2)-rich cells in slightly acidic micro-environment, has emerged as a new method in tumor treatment. Herein, we manufactured ultrasmall dopamine-modified hyaluronic acid (HD)- stabilized Fe(III)-tannic acid nanoparticles (HFTNPs). HFTNPs can specifically accumulate in inflammatory macrophages in atherosclerotic plaques, provide brighter magnetic resonance images, promote reactive oxygen species (ROS) generation, and induce the death of inflammatory macrophages without damaging normal cells and tissues. In conclusion, HFTNPs have a tremendous potential as safe and effective diagnostic and therapeutic reagents for atherosclerosis.