A tale of two clades: monkeypox viruses
A tale of two clades: monkeypox viruses
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DOI：
10.1099/vir.0.81215-0
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发表时间：
2005-10-01
影响因子：
3.8
通讯作者：
Damon, IK
中科院分区：
文献类型：
--
作者：
Likos, AM;Sammons, SA;Damon, IK
人类猴痘于2003年在美国爆发期间首次在非洲以外得到确认，该疫情可追溯至输入性猴痘病毒（MPXV）感染的西非啮齿动物。与刚果民主共和国（刚果盆地国家）描述的天花样疾病不同，美国的疾病似乎较温和。在这里，利用美国和刚果盆地暴发的数据，分析比较了确诊的人类猴痘病例的临床、实验室和流行病学特征，结果表明人类疾病的致病性与病毒株有关。美国、西非和中非MPXV分离株的基因组测序证实存在两个MPXV分支。MPXV进化支之间开放阅读框的比较允许预测可能导致这两个进化支之间观察到的人类致病性差异的病毒蛋白。了解猴痘病毒的分子发病机制、临床和流行病学特性，有助于提高猴痘的防治水平。
Human monkeypox was first recognized outside Africa in 2003 during an outbreak in the USA that was traced to imported monkeypox virus (MPXV)-infected West African rodents. Unlike the smallpox-like disease described in the Democratic Republic of the Congo (DRC; a Congo Basin country), disease in the USA appeared milder. Here, analyses compared clinical, laboratory and epidemiological features of confirmed human monkeypox case-patients, using data from outbreaks in the USA and the Congo Basin, and the results suggested that human disease pathogenicity was associated with the viral strain. Genomic sequencing of USA, Western and Central African MPXV isolates confirmed the existence of two MPXV clades. A comparison of open reading frames between MPXV clades permitted prediction of viral proteins that could cause the observed differences in human pathogenicity between these two clades. Understanding the molecular pathogenesis and clinical and epidemiological properties of MPXV can improve monkeypox prevention and control.