Enhanced Hyperthermia Induced by MDMA in Parkin Knockout Mice.
Enhanced Hyperthermia Induced by MDMA in Parkin Knockout Mice.
复制标题
DOI：
10.2174/157015911795016985
复制
发表时间：
2011-03
影响因子：
5.3
通讯作者：
Ikeda K
中科院分区：
文献类型：
--
作者：
Takamatsu Y;Shiotsuki H;Kasai S;Sato S;Iwamura T;Hattori N;Ikeda K
据报道，MDMA（3，4-亚甲二氧基甲基苯丙胺）对多巴胺（DA）和5-羟色胺神经元都有严重毒性。MDMA显着减少黑质中的DA神经元的数量，但不是在黑质核，表明MDMA导致选择性破坏黑质纹状体通路中的DA神经元，保留中脑边缘通路。帕金森病（Parkinson's disease，PD）是一种多因素引起的神经退行性疾病。PD的病理标志是黑质纹状体通路中DA能神经元的变性。在人类常染色体隐性遗传性帕金森综合征中经常观察到帕金基因突变。假设帕金蛋白可以防止神经毒性损伤，我们试图用帕金蛋白基因敲除小鼠来阐明帕金蛋白在MDMA诱导的体温过高（神经元损伤的原因之一）中的作用。在22 ± 2°C的环境温度下，在腹膜内注射MDMA（30 mg/kg）之前和之后15、30、45和60 min测量直肠体温。与野生型小鼠相比，在杂合和纯合parkin基因敲除小鼠中观察到MDMA注射后显着增强的高热，表明parkin在MDMA神经毒性中起保护作用。
MDMA (3,4-methylenedioxymethamphetamine) is reportedly severely toxic to both dopamine (DA) and serotonin neurons. MDMA significantly reduces the number of DA neurons in the substantia nigra, but not in the nucleus accumbens, indicating that MDMA causes selective destruction of DA neurons in the nigrostriatal pathway, sparing the mesolimbic pathway. Parkinson’s disease (PD) is a neurodegenerative disorder of multifactorial origin. The pathological hallmark of PD is the degeneration of DA neurons in the nigrostriatal pathway. Mutations in the parkin gene are frequently observed in autosomal recessive parkinsonism in humans. Parkin is hypothesized to protect against neurotoxic insult, and we attempted to clarify the role of parkin in MDMA-induced hyperthermia, one of the causal factors of neuronal damage, using parkin knockout mice. Body temperature was measured rectally before and 15, 30, 45, and 60 min after intraperitoneal injection of MDMA (30 mg/kg) at an ambient temperature of 22 ± 2°C. Significantly enhanced hyper-thermia after MDMA injection was observed in heterozygous and homozygous parkin knockout mice compared with wildtype mice, suggesting that parkin plays a protective role in MDMA neurotoxicity.
登录
查看更多内容
影响因子：
7.3
作者：
Mechan, AO;Esteban, B;Green, AR
通讯作者：
Green, AR
影响因子：
4.7
作者：
Granado, Noelia;O'Shea, Esther;Moratalla, Rosario
通讯作者：
Moratalla, Rosario
影响因子：
7.3
作者：
Colado, MI;Camarero, J;Green, AR
通讯作者：
Green, AR
影响因子：
82.9
作者：
Xu, J;Kao, SY;Yankner, BA
通讯作者：
Yankner, BA
影响因子：
5.3
作者：
Doly, Stephane;Valjent, Emmanuel;Maroteaux, Luc
通讯作者：
Maroteaux, Luc