Increased toxicity to invertebrates associated with a mixture of atrazine and organophosphate insecticides
Increased toxicity to invertebrates associated with a mixture of atrazine and organophosphate insecticides
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DOI：
10.1002/etc.5620210724
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发表时间：
2002-07
影响因子：
4.1
通讯作者：
T. Anderson;M. Lydy
中科院分区：
文献类型：
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作者：
T. Anderson;M. Lydy
本研究探讨了阿特拉津与三种有机磷杀虫剂（毒死蜱、甲基双硫磷和二嗪农）对水玻璃虫和家蝇的联合毒性。采用析因设计，评价了每种OP的致死浓度/致死剂量（LC 1/LD 1、LC 5/LD 5、LC 15/LD 15和LC 50/LD 50）与0、10、40、80和200 μg/L阿特拉津对H. Azteca和M.南极洲阿特拉津浓度（>40 μg/L）与每种OP联合使用时，对H. Azteca与单独给药的OP相比。乙酰胆碱酯酶（AChE）的活性也进行了检查的个人OP与阿特拉津治疗。阿特拉津与每一种OP的组合导致乙酰胆碱酯酶活性的显着降低，与单独给药的OP相比。此外，H.用莠去津（>40 μg/L）预处理的阿兹特克对OP杀虫剂的敏感性明显高于H.在测试前未用阿特拉津预处理的阿兹特克。局部暴露于阿特拉津浓度并没有显著增加OP对M的毒性。南极洲这项研究的结果表明，接触环境混合物的生物体的毒性可能会增加。
This study examined the joint toxicity of atrazine and three organophosphate (OP) insecticides (chlorpyrifos, methyl parathion, and diazinon) exposed to Hyalella azteca and Musca domestica. A factorial design was used to evaluate the toxicity of binary mixtures in which the lethal concentration/lethal dose (LC1/LD1, LC5/LD5, LC15/LD15, and LC50/LD50) of each OP was combined with atrazine concentrations of 0, 10, 40, 80, and 200 μg/L for H. azteca and 0, 200, and 2,000 ng/mg for M. domestica. Atrazine concentrations (>40 μg/L) in combination with each OP caused a significant increase in toxicity to H. azteca compared with the OPs dosed individually. Acetylcholinesterase (AChE) activity also was examined for the individual OPs with and without atrazine treatment. Atrazine in combination with each of the OPs resulted in a significant decrease in AChE activity compared with the OPs dosed individually. In addition, H. azteca that were pretreated with atrazine (>40 μg/L) were much more sensitive to the OP insecticides compared with H. azteca that were not pretreated with atrazine before being tested. Topical exposure to atrazine concentrations did not significantly increase OP toxicity to M. domestica. The results of this study indicate the potential for increased toxicity in organisms exposed to environmental mixtures.