Breaking up MTDH-SND1 to break down metastasis.

Breaking up MTDH-SND1 to break down metastasis.
复制标题

破坏 MTDH-SND1 以破坏转移。

DOI:
10.1038/s43018-021-00320-7
复制
发表时间:
2022
期刊:
影响因子:
22.7
通讯作者:
Ganesh,Karuna
Ganesh,Karuna
中科院分区:
医学1区
文献类型:
--
作者:
Jiang,Qingwen;Ganesh,Karuna

文献摘要

相似文献

尽管已经确定了许多潜在靶点,但仍然缺乏针对转移性癌症的有效、特异性疗法。现在有两项研究确定了 MTDH-SND1 相互作用的小分子抑制剂,可通过协调一致的癌细胞自主效应和免疫调节来有效抑制乳腺癌的进展和转移。
Although many potential targets have been identified, effective, specific therapies for metastatic cancers are still lacking. Two studies now identify small-molecule inhibitors of MTDH–SND1 interaction that potently suppress breast cancer progression and metastasis via concerted cancer-cell-autonomous effects and immune modulation.