Visual inspection in oral cancer screening in Cuba: a case-control study
Visual inspection in oral cancer screening in Cuba: a case-control study
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DOI：
10.1016/s1368-8375(01)00033-1
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发表时间：
2002-02-01
期刊：
影响因子：
4.8
通讯作者：
Salva, AR
中科院分区：
文献类型：
--
作者：
Sankaranarayanan, R;Garrote, LF;Salva, AR
进行了一项病例对照研究，以评估古巴正在进行的口腔癌筛查方案在预防古巴晚期口腔癌方面的效果。该研究的病例包括200名III期和IV期口腔癌患者。每个病例招募三名表面健康的受试者作为对照，这些受试者的性别、年龄（± 5岁）匹配，居住在病例所在房屋的200英寸范围内，并愿意接受采访。通过与受试者进行个人访谈，收集有关社会经济指标、吸烟、饮酒、饮食和以牙医就诊形式的筛查史的信息，诊断为晚期口腔癌的比值比（OR），95%置信区间（CI），与病例诊断日期的筛查经验相关，1，2，3，6，对病例确诊前12个月的资料进行条件Logistic回归分析。与筛查相关的晚期口腔癌与病例诊断前3个月的筛查经验相关的比值比为0.67（95%CI：0.46-0.95）。单次筛查的优势比为0.91（95% CI：0.60-1.37），两次或多次筛查的优势比为0.41（95% CI：0.24-0.68）。筛查提供的保护自上次检测以来持续长达3年。对该方案进行描述性评价的结果还显示，在方案实施后，从高级阶段向早期阶段转变的证据有限。尽管如此，鉴于研究中的几个局限性，应谨慎解释结果。特别是事实上，筛查史是通过采访间接建立的，并且构成病例的是晚期口腔癌，而不是死于该疾病的人。(C)2002爱思唯尔科技有限公司。保留所有权利。
A case-control study was conducted to evaluate the efficacy of an on-going oral cancer screening programme in Cuba in preventing advanced oral cancer in Cuba. The cases for the study consisted of 200 oral cancer patients with stage III and IV disease. Three apparently healthy subjects per case, matched for sex, age (plus or minus 5 years) and residing within a perimeter of 200 in of the house with the case, and willing to be interviewed, were recruited as the controls. Information on socio-economic indicators, smoking, drinking, diet and screening history in the form of visits to the dentist were collected by personal interview with the subjects, Odds ratio (OR), with 95% confidence intervals (CI), of being diagnosed with an advanced oral cancer, in relation to the screening experience at the date of diagnosis of case, 1, 2, 3, 6, and 12 months prior to the date of diagnosis of case were estimated by conditional logistic regression for matched data. The odds ratio of advanced oral cancer associated with screening in relation to screening experience 3 months prior to the diagnosis of the case was 0.67 (95% CI: 0.46-0.95). The odds ratio was 0.91 (95% CI: 0.60-1.37) for a single screening test and 0.41 (95% Cl: 0.24-0.68) for two or more tests. The protection offered by screening persisted up to 3 years since the last test. The results of a descriptive evaluation of the programme also revealed limited evidence towards a shift from advanced to early stages after the introduction of the programme. Nonetheless, the results should be interpreted with caution in view of the several limitations in the study. particularly the fact that screening history was established indirectly by interviews and advanced oral cancers constituted the cases, rather than those who died from the disease. (C) 2002 Elsevier Science Ltd. All rights reserved.