Fgf18 is required for embryonic lung alveolar development.
Fgf18 is required for embryonic lung alveolar development.
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DOI：
10.1016/j.bbrc.2004.07.198
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发表时间：
2004-09
影响因子：
3.1
通讯作者：
H. Usui;Masaki Shibayama;N. Ohbayashi;M. Konishi;S. Takada;N. Itoh
中科院分区：
文献类型：
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作者：
H. Usui;Masaki Shibayama;N. Ohbayashi;M. Konishi;S. Takada;N. Itoh
Fgf18在小鼠胚胎肺中大量表达。为了阐明Fgf18在小鼠胚胎肺发育中的作用，我们检测了Fgf18−/−胚胎肺。虽然Fgf18 - / -肺的大小在外观上略小于野生型肺，但Fgf18 - / -肺的近端和远端气道分支均未受损。然而，E18.5的Fgf18−/−肺的肺泡空间减少，间质间室变厚，并且有许多嵌入的毛细血管。Fgf18 - / -肺中的细胞增殖也在E17.5左右短暂减少，尽管Fgf18 - / -肺中肺上皮细胞标记基因的表达并未受损。本研究结果表明，Fgf18在胚胎肺发育晚期的肺泡发育中起作用。Fgf18刺激末囊期细胞增殖可能参与远端肺重构。
Fgf18 is abundantly expressed in mouse embryonic lungs. To elucidate the roles of Fgf18 in mouse embryonic lung development, we examined the Fgf18−/− embryonic lungs. Although the sizes of the Fgf18−/− lungs were a little smaller in appearance than those of wild-type lungs, neither proximal nor distal airway branching in the Fgf18−/− lungs was impaired. However, the Fgf18−/− lungs at E18.5 had reduced alveolar space, thicker interstitial mesenchymal compartments, and many embedded capillaries. Cell proliferation in the Fgf18−/− lungs was also transiently reduced around E17.5, although the expression of marker genes for lung epithelial cells in the Fgf18−/− lungs was not impaired. The present findings indicate that the Fgf18 plays roles in lung alveolar development during late embryonic lung development stages. The cell proliferation during the terminal saccular stage stimulated by Fgf18 might play roles in the remodeling of the distal lung.