MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity.

MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity.
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DOI:
10.1016/j.stem.2010.06.011
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发表时间:
2010-07-02
期刊:
影响因子:
23.9
通讯作者:
Gregory RI
Gregory RI
中科院分区:
医学1区
文献类型:
--
作者:
Martinez NJ;Gregory RI

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了解胚胎干细胞(ESC)自我更新和多能性的分子基础将有助于这些非凡细胞的治疗开发。在这里,我们将讨论microRNA在建立和维持ESC身份中的新作用,并总结我们目前对控制microRNA在ESC中表达和功能的机制的理解。
Understanding the molecular foundations of embryonic stem cell (ESC) self-renewal and pluripotency will facilitate therapeutic exploitation of these remarkable cells. Here we discuss the emerging roles of microRNAs in the establishment and maintenance of ESC identity and summarize our current understanding of the mechanisms controlling microRNA expression and function in ESCs.
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