N-glycans of growth factor receptors: their role in receptor function and disease implications.
N-glycans of growth factor receptors: their role in receptor function and disease implications.
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DOI：
10.1042/cs20160273
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发表时间：
2016-10
期刊：
影响因子：
6
通讯作者：
Motoko Takahashi;Y. Hasegawa;Cong‐xiao Gao;Y. Kuroki;N. Taniguchi
中科院分区：
文献类型：
--
作者：
Motoko Takahashi;Y. Hasegawa;Cong‐xiao Gao;Y. Kuroki;N. Taniguchi
许多与信号转导相关的分子都是分泌蛋白或膜蛋白，这些分子受糖链调控的机制对于理解细胞发生的事件是一个非常重要的问题。本文综述了N-糖链对表皮生长因子受体、ErbB3和转化生长因子β受体(TGFR-β)的功能调节。本文综述了N-葡聚糖在调节蛋白质构象和与糖类识别分子相互作用中的重要作用。这些结果表明了一种控制细胞信号转导和开发基于糖链的新疗法的新策略的可能性。
Numerous signal-transduction-related molecules are secreted proteins or membrane proteins, and the mechanism by which these molecules are regulated by glycan chains is a very important issue for developing an understanding of the cellular events that transpire. This review covers the functional regulation of epidermal growth factor receptor (EGFR), ErbB3 and the transforming growth factor β (TGF-β) receptor by N-glycans. This review shows that the N-glycans play important roles in regulating protein conformation and interactions with carbohydrate recognition molecules. These results point to the possibility of a novel strategy for controlling cell signalling and developing novel glycan-based therapeutics.