NONCOMPETITIVE N-METHYL-D-ASPARTATE ANTAGONISTS ARE POTENT ACTIVATORS OF VENTRAL TEGMENTAL A10 DOPAMINE NEURONS
NONCOMPETITIVE N-METHYL-D-ASPARTATE ANTAGONISTS ARE POTENT ACTIVATORS OF VENTRAL TEGMENTAL A10 DOPAMINE NEURONS
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DOI：
10.1016/0304-3940(90)90823-r
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发表时间：
1990-11-13
影响因子：
2.5
通讯作者：
CECI, A
中科院分区：
文献类型：
--
作者：
FRENCH, ED;CECI, A
The response of ventral tegmental (VTA) A10 dopamine neurons to a series of compounds covering the spectrum from high-affinity phencyclidine receptor ligands (MK-801, PCP) to high-affinity .sigma.-receptor ligands ((+)-pentazocine, DTG) was measured using single-unit extracellular recording techniques in the rat. Dose-response comparisons revealed that MK-801 was 3, 6, 19 and 119 times more potent at activating A10 neurons than PCP, (+)-SKF-10,047, ketamine and (+)-pentazocine, respectively. DTG (1,3-di-o-tolylguanidine), the most selective .sigma.-ligand, and U50,488H, a .kappa.-opiate, failed to produce any stimulation of firing. Also, pretreatment with haloperidol, a potent .sigma.-receptor ligand, did not prevent MK-801-induced excitations. Thus, the activation of the A10-mesolimbic-mesocortical dopamine pathways by PCP, PCP-like drugs and .sigma.-psychotomimetics is mediated by the PCP receptor, not the haloperidol-sensitive .sigma.-receptor, with potencies directly correlated to their activity as non-competitive N-methyl-D-aspartate (NMDA) antagonists.
