Colorectal Cancer Incidence Among Young Adults in California
Colorectal Cancer Incidence Among Young Adults in California
复制标题
DOI：
10.1089/jayao.2014.0006
复制
发表时间：
2014-12-01
影响因子：
2
通讯作者：
Zell, Jason A.
中科院分区：
文献类型：
--
作者：
Singh, Kathryn E.;Taylor, Thomas H.;Zell, Jason A.
目的：结直肠癌 (CRC) 发病率在过去三十年中有所下降，这主要归功于筛查工作。对于 20-39 岁年轻人 (YA) 人群中 CRC 的发病率知之甚少，因为一般风险个体的筛查通常从 50 岁开始。我们检查了 CRC 发病率，重点关注青少年，以确定高风险亚组。方法：我们分析了 1988 年至 2009 年期间来自加州癌症登记处的 231,544 例 CRC 病例（包括 5617 例 20-39 岁青少年）。我们按种族/族裔、性别和结直肠肿瘤位置评估了特定年龄的发病率，并计算了半年百分比变化 (BAPC)，以监测 22 年研究期间的发病率变化。结果：20-29 岁和 30-39 岁年龄段的 CRC 绝对发病率较低（每 100,000 人中 0.7 例为西班牙裔和非裔美国女性） 20-29 岁的 30-39 岁亚洲/太平洋岛民男性中，每 100,000 人中有高达 5.0 人）。然而，我们观察到，随着时间的推移，青少年群体中男性和女性的 CRC 发病率均呈上升趋势，尤其是 20-29 岁西班牙裔女性的远端结肠癌 (BAPC= + 15.9%；p < 0.042)。结论：青少年群体中 CRC 的绝对发病率仍然远低于 50 岁及以上成年人。然而，年轻人中的结直肠癌发病率正在上升，而筛查人群中成年人（50 岁及以上）的发病率则呈下降趋势。需要更多的研究来更好地描述结直肠癌风险增加的青少年的特征。
Purpose: Colorectal cancer (CRC) incidence has decreased over the past three decades, due largely to screening efforts. Relatively little is known about CRC incidence among the young adult (YA) population ages 20-39, as screening typically commences at age 50 for average-risk individuals. We examined CRC incidence with a focus on YAs in order to identify high-risk subgroups.Methods: We analyzed 231,544 incident CRC cases from 1988-2009 (including 5617 YAs 20-39 years of age) from the California Cancer Registry. We assessed age-specific incidence rates by race/ethnicity, gender, and colorectal tumor location, and calculated the biannual percent change (BAPC) to monitor change in incidence over the 22-year study period.Results: The absolute incidence of CRC per 100,000 was low among YAs 20-29 and 30-39 years old (ranging from 0.7 per 100,000 among Hispanic and African American females aged 20-29 up to 5.0 per 100,000 among Asian/Pacific Islander males aged 30-39). However, we observed increasing CRC incidence rates over time among both males and females in the YA population, particularly for distal colon cancer in Hispanic females aged 20-29 (BAPC= + 15.9%; p < 0.042).Conclusion: The absolute incidence of CRC remains far lower for YAs than among adults aged 50 and over. However, CRC incidence is increasing among young adults, in contrast to the decreasing rates observed for adults in the screened population (aged 50 and above). More research is needed to better characterize YAs at increased risk for CRC.