Prognostic value of glucose transporter 3 expression in hepatocellular carcinoma.
Prognostic value of glucose transporter 3 expression in hepatocellular carcinoma.
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DOI：
10.3892/ol.2019.11191
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发表时间：
2020-01-01
期刊：
影响因子：
2.9
通讯作者：
Lu, Jun
中科院分区：
文献类型：
--
作者：
Gao, Hengjun;Hao, Yijie;Lu, Jun
确定一种有效的生物标志物来预测肝细胞癌（HCC）患者的预后可能会提高患者的生存率。本研究旨在探讨葡萄糖转运蛋白3（GLUT-3）在肝癌中的表达及其对肝癌患者生存的预测价值。免疫组化分别检测275例和140例HCC患者HCC组织中GLUT-3的表达。分析GLUT-3表达与HCC患者临床病理特征之间的关系，以及GLUT-3表达与患者生存率之间的关系。GLUT-3表达的预测值使用验证群组证实。结果表明，肝癌组织中GLUT-3高表达与甲胎蛋白水平升高、肿瘤体积大、组织分化差、肿瘤淋巴结转移分期为III期和IV期显著相关（P
Determining an effective biomarker for predicting the prognosis of patients with hepatocellular carcinoma (HCC) may improve patient survival rates. The present study aimed to investigate the expression of glucose transporter 3 (GLUT-3) in HCC and to determine its predictive value for the survival of patients with HCC. Immunohistochemistry was used to detect GLUT-3 expression in HCC tissues of 275 and 140 patients with HCC from training and validation cohorts, respectively. The association between GLUT-3 expression and the clinicopathological characteristics of patients with HCC, and between GLUT-3 expression and patient survival rates were analyzed. The predictive value of GLUT-3 expression was confirmed using the validation cohort. The results demonstrated that the high GLUT-3 expression in HCC tissues was significantly associated with elevated alpha-fetoprotein level, large tumor size, poor histological differentiation and Tumor-Node-Metastasis stages III and IV (P