Small Sample Research: Considerations Beyond Statistical Power

Small Sample Research: Considerations Beyond Statistical Power
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DOI:
10.1007/s11121-015-0585-4
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发表时间:
2015-10-01
期刊:
影响因子:
3.5
通讯作者:
Arroyo, Judith A.
Arroyo, Judith A.
中科院分区:
医学2区
文献类型:
--
作者:
Etz, Kathleen E.;Arroyo, Judith A.

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小样本研究对目前的设计和分析方法标准以及构成良好预防科学的基本概念提出了挑战。然而,小样本研究至关重要,因为小样本中提出的研究问题往往代表了弱势和代表性不足人群的严重健康问题。这篇评论考虑了关于小样本研究的特别部分,并强调了特别部分没有考虑的小样本研究中出现的其他挑战,包括可推广性,确定什么是知识,以及确保研究设计符合社区的愿望。它还指出了小样本研究所提供的机会,例如关注和增加对背景的理解,以及它可能对随机临床试验的替代方案的重视。评注敦促制定和采用创新战略,开展小样本研究。
Small sample research presents a challenge to current standards of design and analytic approaches and the underlying notions of what constitutes good prevention science. Yet, small sample research is critically important as the research questions posed in small samples often represent serious health concerns in vulnerable and underrepresented populations. This commentary considers the Special Section on small sample research and also highlights additional challenges that arise in small sample research not considered in the Special Section, including generalizability, determining what constitutes knowledge, and ensuring that research designs match community desires. It also points to opportunities afforded by small sample research, such as a focus on and increased understanding of context and the emphasis it may place on alternatives to the randomized clinical trial. The commentary urges the development and adoption of innovative strategies to conduct research with small samples.