ATP-INDUCED CONFORMATIONAL-CHANGES IN RESTRICTION ENDONUCLEASE FROM ESCHERICHIA-COLI K-12
ATP-INDUCED CONFORMATIONAL-CHANGES IN RESTRICTION ENDONUCLEASE FROM ESCHERICHIA-COLI K-12
复制标题
DOI：
10.1073/pnas.75.7.3099
复制
发表时间：
1978-01-01
影响因子：
11.1
通讯作者：
YUAN, R
中科院分区：
文献类型：
--
作者：
BICKLE, TA;BRACK, C;YUAN, R
ATP诱导E.大肠杆菌K-12限制性内切酶[EcoK]，使其能够区分未修饰的和修饰的DNA识别序列。这种构象变化不需要ATP水解。ATP水解是DNA切割的必要条件。
ATP induces a conformational change in the E. coli K-12 restriction enzyme [EcoK] that allows it to discriminate between unmodified and modified DNA recognition sequences. This conformational change does not require ATP hydrolysis. ATP hydrolysis is a requirement for DNA cleavage.