Partial replication of two rumination-related candidate gene studies.
Partial replication of two rumination-related candidate gene studies.
复制标题
两项与沉思相关的候选基因研究的部分复制。
DOI：
10.1080/02699931.2016.1168779
复制
发表时间：
2017
影响因子：
2.6
通讯作者：
Goldsmith,HHill
中科院分区：
文献类型：
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作者：
VanHulle,CarolA;Clifford,Sierra;Moore,MollieN;Lemery-Chalfant,Kathryn;Goldsmith,HHill
最近的两篇论文将候选基因与沉思反刍相关联，沉思反刍是8-14岁儿童抑郁症的一种可能的认知内表型。Stone等报道BDNF val 66 met多态性可预测青春期的沉思。Woody等报道，携带至少一个CRHR 1 TAT单倍型拷贝的儿童在母亲抑郁症的情况下比同龄人报告的沉思更少。我们试图在12-16岁的双胞胎样本中复制和扩展这些发现。我们分析了BDNF val 66 met（rs6265）多态性和Woody等人用于创建CRHR 1单倍型的三个单核苷酸多态性（SNP）中的两个（rs 242924和rs7209436）。我们控制了母亲的抑郁症史和家庭内的聚集性。与斯通等人不同，我们发现BDNF Met携带者的沉思程度更高。这一主要效应通过与青春期状态的相互作用进行了限定，该效应由身体更成熟的参与者驱动。与伍迪等人类似，我们发现CRHR 1单核苷酸多态性与母亲抑郁症之间存在相互作用，在母亲抑郁症存在的情况下，纯合的次要基因型作为保护因子，防止育雏。研究结果提供了部分支持的候选基因在两个环境敏感的系统育雏的影响。
Two recent papers associated candidate genes with brooding rumination, a possible cognitive endophenotype for depression, in children ages 8–14 years. Stone et al. reported that BDNF val66met polymorphism predicted brooding in adolescence. Woody et al. reported that children carrying at least one copy of a CRHR1TAThaplotype reported less brooding than their peers in the presence of maternal depression. We attempted to replicate and extend these findings in a sample of twins aged 12–16 years. We analyzed the BDNF val66met (rs6265) polymorphism and two (rs242924 and rs7209436) out of three single nucleotide polymorphisms (SNPs) that Woody et al. used to create a CRHR1 haplotype. We controlled for maternal history of depression and clustering within families. Unlike Stone et al., we found higher brooding among BDNF Met carriers. This main effect was qualified by an interaction with pubertal status, with the effect driven by more physically mature participants. Similar to Woody et al., we found an interaction between CRHR1 SNPs and maternal depression, with the homozygous minor genotype acting as a protective factor against brooding in the presence of maternal depression. Findings provide partial support for the influence of candidate genes in two environmentally sensitive systems on brooding.