Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease.
Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease.
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常染色体显性阿尔茨海默氏病中次区域丘脑体积与脑病理学之间的关联。
DOI：
10.1093/braincomms/fcab101
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发表时间：
2021
影响因子：
4.8
通讯作者：
Quiroz YT
中科院分区：
文献类型：
--
作者：
Pardilla-Delgado E;Torrico-Teave H;Sanchez JS;Ramirez-Gomez LA;Baena A;Bocanegra Y;Vila-Castelar C;Fox-Fuller JT;Guzmán-Vélez E;Martínez J;Alvarez S;Ochoa-Escudero M;Lopera F;Quiroz YT
组织学报告表明，调节多种生理和认知过程的丘脑亚区域并不均匀地受到阿尔茨海默病的影响。尽管如此，结构神经影像学研究通常认为丘脑是一个单一的区域。在体内阿尔茨海默氏症依赖的体积变化，丘脑亚区的鉴定可能有助于阿尔茨海默氏症的早期细胞核特异性神经变性的表征。在这里，我们利用最大的常染色体显性阿尔茨海默病单突变队列来测试非痴呆突变携带者（n = 31）与非携带者（n = 36）相比，次区域丘脑体积的横断面异常是否明显，以及次区域丘脑体积是否与年龄，脑病理学标志物和认知能力相关。使用自动包裹，我们检查了丘脑的六个亚区（前，侧，腹，intralaminar，内侧，和后）和他们的关系，年龄和脑病理（淀粉样蛋白和tau蛋白），通过PET成像测量。在丘脑亚区的体积中未观察到组间差异。在携带者中，内侧亚区的较低体积与皮质淀粉样蛋白和内嗅tau蛋白负荷增加有关。这些研究结果表明，丘脑阿尔茨海默氏症相关的体积减少是不均匀的，即使在常染色体显性阿尔茨海默氏症的临床前和前驱期，因此，这种结构不应该被认为是一个单一的，单一的结构在阿尔茨海默氏症的研究。Pardilla-Delgado等人研究了常染色体显性阿尔茨海默病患者，发现在临床发作前数年，较低的内侧和后丘脑次区域体积与更大的淀粉样蛋白和tau蛋白负荷相关。研究结果表明，研究丘脑子区域可以提高我们对该结构在阿尔茨海默病中的作用的理解。
Histopathological reports suggest that subregions of the thalamus, which regulates multiple physiological and cognitive processes, are not uniformly affected by Alzheimer’s disease. Despite this, structural neuroimaging studies often consider the thalamus as a single region. Identification of in vivo Alzheimer’s-dependent volumetric changes in thalamic subregions may aid the characterization of early nuclei-specific neurodegeneration in Alzheimer’s disease. Here, we leveraged access to the largest single-mutation cohort of autosomal-dominant Alzheimer’s disease to test whether cross-sectional abnormalities in subregional thalamic volumes are evident in non-demented mutation carriers (n = 31), compared to non-carriers (n = 36), and whether subregional thalamic volume is associated with age, markers of brain pathology and cognitive performance. Using automatic parcellation we examined the thalamus in six subregions (anterior, lateral, ventral, intralaminar, medial, and posterior) and their relation to age and brain pathology (amyloid and tau), as measured by PET imaging. No between-group differences were observed in the volume of the thalamic subregions. In carriers, lower volume in the medial subregion was related to increased cortical amyloid and entorhinal tau burden. These findings suggest that thalamic Alzheimer’s-related volumetric reductions are not uniform even in preclinical and prodromal stages of autosomal-dominant Alzheimer’s disease and therefore, this structure should not be considered as a single, unitary structure in Alzheimer’s disease research. Pardilla-Delgado et al. studied individuals with autosomal-dominant Alzheimer’s disease and found that lower medial and posterior thalamic subregional volumes were associated with greater amyloid and tau burden, years before clinical onset. Findings suggest that studying thalamic sub-regions could improve our understanding of the role of this structure in Alzheimer’s disease.
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影响因子：
9.9
作者：
Cash DM;Ridgway GR;Liang Y;Ryan NS;Kinnunen KM;Yeatman T;Malone IB;Benzinger TL;Jack CR Jr;Thompson PM;Ghetti BF;Saykin AJ;Masters CL;Ringman JM;Salloway SP;Schofield PR;Sperling RA;Cairns NJ;Marcus DS;Xiong C;Bateman RJ;Morris JC;Rossor MN;Ourselin S;Fox NC;Dominantly Inherited Alzheimer Network (DIAN)
通讯作者：
Dominantly Inherited Alzheimer Network (DIAN)
DOI：
10.1093/brain/awt065
发表时间：
2013-05
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Ryan NS;Keihaninejad S;Shakespeare TJ;Lehmann M;Crutch SJ;Malone IB;Thornton JS;Mancini L;Hyare H;Yousry T;Ridgway GR;Zhang H;Modat M;Alexander DC;Rossor MN;Ourselin S;Fox NC
通讯作者：
Fox NC
影响因子：
9.9
作者：
Dickerson, B. C.;Stoub, T. R.;deToledo-Morrell, L.
通讯作者：
deToledo-Morrell, L.
影响因子：
9
作者：
Hanseeuw, Bernard J.;Lopera, Francisco;Quiroz, Yakeel T.
通讯作者：
Quiroz, Yakeel T.
影响因子：
16.2
作者：
Shine, James M.;Hearne, Luke J.;Cocchi, Luca
通讯作者：
Cocchi, Luca