Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS
Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS
复制标题
DOI：
10.1152/ajplung.00380.2014
复制
发表时间：
2015-06-01
影响因子：
4.9
通讯作者：
Calfee, Carolyn S.
中科院分区：
文献类型：
--
作者：
Kangelaris, Kirsten Neudoerffer;Prakash, Arun;Calfee, Carolyn S.
导致脓毒症患者急性呼吸窘迫综合征（ARDS）发展的早期事件序列仍未充分了解。本研究的目的是确定疾病早期基因表达的变化，此时损伤机制可能提供最相关的治疗和预后靶点。我们收集了三级医疗中心急诊部24小时内转入重症监护病房的危重患者的全血RNA。将脓毒症合并ARDS患者与单纯脓毒症患者的全基因组表达进行比较。我们选择了具有>.1 log(2)倍变化和错误发现率的基因
The early sequence of events leading to the development of the acute respiratory distress syndrome (ARDS) in patients with sepsis remains inadequately understood. The purpose of this study was to identify changes in gene expression early in the course of illness, when mechanisms of injury may provide the most relevant treatment and prognostic targets. We collected whole blood RNA in critically ill patients admitted from the Emergency Department to the intensive care unit within 24 h of admission at a tertiary care center. Whole genome expression was compared in patients with sepsis and ARDS to patients with sepsis alone. We selected genes with >1 log(2) fold change and false discovery rate