LIFE-STYLE AND OCCUPATIONAL RISK-FACTORS IN CANCER OF THE LOWER URINARY-TRACT
LIFE-STYLE AND OCCUPATIONAL RISK-FACTORS IN CANCER OF THE LOWER URINARY-TRACT
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DOI：
10.1093/oxfordjournals.aje.a114430
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发表时间：
1986-10-01
影响因子：
5
通讯作者：
SCHUBERT, H
中科院分区：
文献类型：
--
作者：
CLAUDE, J;KUNZE, E;SCHUBERT, H
在一项关于德国北部下尿道癌的配对病例对照研究中，340名男性和91名女性在1977至1982年间接受了采访，结果发现吸烟者与不吸烟者相比，男性的优势比为2.3，女性的优势比为2.9。观察到香烟消费量的增加存在显著的剂量-反应关系，而戒烟者的风险显著降低。橡胶、塑料、染料、纺织和采矿行业的工作与更高的风险相关，接触喷漆、煤沥青、铬和锌的风险比也增加。控制吸烟，在男性中，每天喝咖啡超过4杯的风险增加了2.3，每天消费0.5-1.0升啤酒和超过1.0升啤酒的显著优势比分别为2.1和2.8。研究发现，每天液体摄入量超过2升的优势比为4.0。经常食用罐头食品和油腻食物等饮食习惯与较高的风险相关，而经常食用水果和蔬菜与较低的风险相关。采用多元Logistic回归分析了14个在病例对照研究中起重要作用的决定因素。
In a matched case-control study of cancer of the lower urinary tract in northern Germany in which 340 male and 91 female case-control pairs were interviewed between 1977 and 1982, cigarette smokers were found to have an odds ratio of 2.3 for males and 2.9 for females compared with nonsmokers. A significant dose-response relation was observed for increasing cigarette consumption, and a significant decrease in risk was shown for ex-smokers. Employment in rubber, plastics, dye, textiles, and mining industries was associated with a higher risk, and increased odds ratios were also observed for exposure to spray painting, coal pitch, chromium, and zinc. Controlling for smoking, an elevated risk of 2.3 for drinking more than four cups of coffee per day and significant odds ratios of 2.1 and 2.8 for a daily consumption of 0.5-1.0 liter and above 1.0 liter of beer, respectively, were noted among men. A highly significant odds ratio of 4.0 was found for a daily fluid intake of more than 2 liters. Dietary habits such as the frequent consumption of canned food and fatty meals were associated with a higher risk, whereas a regular consumption of fruits and vegetables was associated with a lower risk. Fourteen determinants found to be important in this case-control series were analyzed by using multiple logistic regression.