Preparation and characterization of an iron oxide-hydroxyapatite nanocomposite for potential bone cancer therapy.
Preparation and characterization of an iron oxide-hydroxyapatite nanocomposite for potential bone cancer therapy.
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DOI：
10.2147/ijn.s79985
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发表时间：
2015
影响因子：
8
通讯作者：
Sundaram NM
中科院分区：
文献类型：
--
作者：
Sneha M;Sundaram NM
近年来，人们发现多功能磁性纳米结构在生物医学和组织工程方面具有潜在的应用前景。氧化铁纳米颗粒具有生物相容性，并具有独特的磁性，使其能够在体内用于药物输送和热疗，并作为磁共振成像的T2造影剂。羟基磷灰石由于其众所周知的生物相容性、生物活性和缺乏毒性而被广泛使用，因此氧化铁和羟基磷灰石材料的组合可能是有用的，因为羟基磷灰石具有更好的骨结合能力。在本研究中，我们制备了氧化铁和羟基磷灰石的纳米复合材料，并分析了它们的物理化学性质。结果表明，这些复合材料具有超顺磁性和生物相容性。这种类型的材料结构将非常适合骨癌治疗和其他生物医学应用。
Recently, multifunctional magnetic nanostructures have been found to have potential applications in biomedical and tissue engineering. Iron oxide nanoparticles are biocompatible and have distinctive magnetic properties that allow their use in vivo for drug delivery and hyperthermia, and as T2 contrast agents for magnetic resonance imaging. Hydroxyapatite is used frequently due to its well-known biocompatibility, bioactivity, and lack of toxicity, so a combination of iron oxide and hydroxyapatite materials could be useful because hydroxyapatite has better bone-bonding ability. In this study, we prepared nanocomposites of iron oxide and hydroxyapatite and analyzed their physicochemical properties. The results suggest that these composites have superparamagnetic as well as biocompatible properties. This type of material architecture would be well suited for bone cancer therapy and other biomedical applications.