Vein graft adaptation and fistula maturation in the arterial environment.
Vein graft adaptation and fistula maturation in the arterial environment.
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DOI：
10.1016/j.jss.2014.01.042
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发表时间：
2014-05-01
影响因子：
2.2
通讯作者：
Dardik, Alan
中科院分区：
文献类型：
--
作者：
Lu, Daniel Y.;Chen, Elizabeth Y.;Wong, Daniel J.;Yamamoto, Kota;Protack, Clinton D.;Williams, Willis T.;Assi, Roland;Hall, Michael R.;Sadaghianloo, Nirvana;Dardik, Alan
在两种常见的外科手术过程中，静脉暴露于动脉环境，即静脉移植物和动静脉瘘（AVF）的创建。在这两种情况下，静脉适应动脉环境，其特征在于与静脉环境相比不同的血液动力学条件和增加的氧张力。静脉对动脉环境的成功适应对于静脉移植物或AVF的长期成功至关重要，并且在这两种情况下通常以静脉扩张和壁增厚为特征。然而，AVF暴露于高流量、高剪切应力、低压动脉环境，并且主要通过向外扩张而适应，内膜增厚较少。静脉移植物暴露于中等流量、中等剪切应力、高压动脉环境，并且主要通过增加壁增厚而较少向外扩张来适应。我们回顾了描述这些差异的数据，以及介导这些过程的潜在分子机制。尽管进行了广泛的研究，但目前在静脉移植物适应性和AVF成熟之间确定的调节细胞增殖和迁移或基质合成、分泌或降解的分子途径几乎没有差异，这是对动脉环境的不同类型的静脉适应性的原因。
Veins are exposed to the arterial environment during two common surgical procedures, creation of vein grafts and arteriovenous fistulae (AVF). In both cases veins adapt to the arterial environment that is characterized by different hemodynamic conditions and increased oxygen tension compared to the venous environment. Successful venous adaptation to the arterial environment is critical for long term success of the vein graft or AVF, and in both cases is generally characterized by venous dilation and wall thickening. However, AVF are exposed to a high flow, high shear stress, low pressure arterial environment, and adapt mainly via outward dilation with less intimal thickening. Vein grafts are exposed to a moderate flow, moderate shear stress, high pressure arterial environment, and adapt mainly via increased wall thickening with less outward dilation. We review the data that describe these differences, as well as the underlying molecular mechanisms that mediate these processes. Despite extensive research, there are few differences in the molecular pathways that regulate cell proliferation and migration or matrix synthesis, secretion, or degradation currently identified between vein graft adaptation and AVF maturation that account for the different types of venous adaptation to arterial environments.
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影响因子：
6.1
作者：
Ene-Iordache, Bogdan;Remuzzi, Andrea
通讯作者：
Remuzzi, Andrea
影响因子：
13.2
作者：
Dixon, BS;Novak, L;Fangman, J
通讯作者：
Fangman, J
DOI：
10.1016/0735-1097(96)00206-9
发表时间：
1996-09-01
影响因子：
24
作者：
FitzGibbon, GM;Kafka, HP;Burton, JR
通讯作者：
Burton, JR
影响因子：
0.9
作者：
Albayrak, Ramazan;Yuksel, Seref;Karaman, Ozcan
通讯作者：
Karaman, Ozcan
影响因子：
4.3
作者：
Bradbury, Andrew W.;Adam, Donald J.;Raab, Gillian M.
通讯作者：
Raab, Gillian M.