Effective synthesis of enantiopure [1,2,3]triazolo[1,5-a]- and pyrazolo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepines by diastereoselective intramolecular azide and nitrilimine cycloadditions
Effective synthesis of enantiopure [1,2,3]triazolo[1,5-a]- and pyrazolo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepines by diastereoselective intramolecular azide and nitrilimine cycloadditions
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DOI：
10.1055/s-2005-869991
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发表时间：
2005-08-19
影响因子：
2.6
通讯作者：
Terraneo, A
中科院分区：
文献类型：
--
作者：
Broggini, G;De Marchi, I;Terraneo, A
通过完全非对映选择性的分子内1，3-偶极环加成反应合成了对映体纯的新型四环1，4-苯并二氮杂卓酮体系。产物的绝对立体化学通过X-射线晶体学确认，对映体纯度通过使用手性HPLC测定。
The synthesis of new tetracyclic 1,4-benzodiazepinonic systems was performed in enantiopure form by totally diastereoselective intramolecular 1,3-dipolar cycloadditions. The absolute stereochemistry of the products was confirmed by X-ray crystallography and the enantiomeric purity was determined by using chiral HPLC.