Von Willebrand factor as a thrombotic and inflammatory mediator in critical illness.
Von Willebrand factor as a thrombotic and inflammatory mediator in critical illness.
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血管性血友病因子在危重病中作为血栓形成和炎症介质
DOI：
10.1111/trf.15667
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发表时间：
2020-06
期刊：
影响因子：
2.9
通讯作者：
Neal, Matthew D.
中科院分区：
文献类型：
--
作者：
Plautz, William E.;Matthay, Zachary A.;Rollins-Raval, Marian A.;Raval, Jay S.;Kornblith, Lucy Z.;Neal, Matthew D.
高分子量多聚血管性血友病因子（vWF）的内皮胞吐可能发生在危重疾病状态，包括创伤和败血症，导致血浆vWF的持续升高和组成改变。这些严重疾病涉及交感肾上腺激活和内皮糖萼丢失的共同过程。作为一种与内皮相互作用的促血栓和促炎症分子，vWF在危重疾病中表现出的改变涉及下游病理的发展和破坏性作用，如弥散性血管内凝血和全身炎症反应综合征。鉴于vWF在这些病理中的作用，最近有一项研究推动进一步了解该分子如何参与相关疾病的病理生理，如创伤性凝血功能障碍和急性肾损伤，这些疾病也被认为是继发于危重疾病状态。阐明vWF在更广泛的广泛性病理中的作用可能为开发新的预防和恢复措施提供基础，同时也为更广泛使用的治疗方法（如含血浆血液制品的管理）提供支撑。
The endothelial exocytosis of high-molecular-weight multimeric von Willebrand factor (vWF) may occur in critical illness states, including trauma and sepsis, leading to the sustained elevation and altered composition of plasma vWF. These critical illnesses involve the common process of sympathoadrenal activation and loss of the endothelial glycocalyx. As a prothrombotic and proinflammatory molecule that interacts with the endothelium, the alterations exhibited by vWF in critical illness have been implicated in the development and damaging effects of downstream pathologies, such as disseminated intravascular coagulation and systemic inflammatory response syndrome. Given the role of vWF in these pathologies, there has been a recent push to further understand how the molecule may be involved in the pathophysiology of related diseases, such as trauma-induced coagulopathy and acute renal injury, which are also known to develop secondarily to critical illness states. Elucidation of the role of vWF across the broader spectrum of generalized pathologies may provide a basis for the development of novel preventative and restorative measures, while also bolstering the scaffold of more widely used treatments, such as the administration of plasma-containing blood products.
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DOI：
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发表时间：
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